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This study aims to test the efficacy of the MovinCog Intervention to enhance cognitive abilities in children 7-15 yrs. The intervention consists of two parts: a physical exercise regimen, based on high-intensity training, and a cognitive training component. The design will contrast the intervention with an active control group, matched for expectancy effects.
Specifically, the investigators will compare both components together (exercise and cognitive training) against either one of the components (exercise alone, or cognitive training alone) and against an active control group. The study will include measures of scholastic aptitude, as well as of working memory and cognitive control (primary outcome measures), two cognitive abilities that are critical to daily life activities, and that respond well to training. In addition, the investigators will measure physiological responses to training, to monitor changes associated with exercise (secondary outcome measures). Finally, the investigators will relate training-specific improvements with transfer gains, to better model the interaction between training and transfer. This will provide a comprehensive understanding of the dynamics associated with the intervention.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise and cognitive training | Experimental | This intervention includes a combination of high-intensity exercise (10min/day) and computerized cognitive training (20min/day). The software for the latter has been developed by our group, and includes 8 mini-games targeting different cognitive abilities. Both are developed for the MovinCog intervention. The intervention is personalized, based on individual performance. |
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| Exercise | Experimental | High-intensity training regimen, 10min/day. Developed for the MovinCog intervention. |
|
| Cognitive training | Experimental | Computerized cognitive training, 20min/day. Developed for the MovinCog intervention. |
|
| Games | Active Comparator | The active control is composed of a blend of board games, computer games, and trivia quizzes. Specific content is personalized based on individual preferences, so as to reflect the flexibility of the experimental arms. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise | Behavioral | Exercise |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline working memory capacity at 10 weeks | Constructs measured by multiple tasks (bds, corsi, n-back) | Baseline and 10-week posttest |
| Change from baseline cognitive control at 10 weeks | Constructs measured by multiple tasks (flanker, go/no-go, stroop) | Baseline and 10-week posttest |
| Change from baseline scholastic aptitude at 10 weeks | Constructs measured by multiple national (New Zealand), standardized tests | Baseline and 10-week posttest |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline resting heart rate at 10 weeks | Measured by monitor | Baseline and 10-week posttest |
| BDNF polymorphism measured by genetic saliva kit | Effect of BDNF polymorphism on primary outcomes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| David Moreau | University of Auckland, New Zealand | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Auckland | Auckland | 1010 | New Zealand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28825973 | Derived | Moreau D, Kirk IJ, Waldie KE. High-intensity training enhances executive function in children in a randomized, placebo-controlled trial. Elife. 2017 Aug 22;6:e25062. doi: 10.7554/eLife.25062. |
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Release IPD at the time of publication.
Post-publication
Unrestricted
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| ID | Term |
|---|---|
| D007859 | Learning Disabilities |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D003147 | Communication Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Cognitive |
| Behavioral |
Cognitive |
|
| Active control | Behavioral | Active control, including a blend of computer games, board games, quizzes, trivia |
|
| Baseline |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D001519 | Behavior |