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| ID | Type | Description | Link |
|---|---|---|---|
| PSI2016-77475R | Other Grant/Funding Number | Ministry of Economy and Competitiveness |
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| Name | Class |
|---|---|
| Ministerio de EconomÃa y Competitividad, Spain | OTHER_GOV |
| Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina | OTHER |
| Universitat Politècnica de Catalunya | OTHER |
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The MoveMent project applies non-pharmacological strategies - physical exercise and cognitive training - that have been shown to be effective in promoting active and healthy aging. The objective is to study the molecular and neural mechanisms of these strategies to stimulate brain plasticity and improve brain health and cognitive functioning.
It is a randomized controlled study with three intervention groups - physical, cognitive and combined - and a control group. The intervention is carried out over 3 months, with a frequency of 5 weekly sessions of 45 minutes each. Cognitive training is applied through a computerized program, physical training consists of a walking aerobic program, and combined training arises from the addition of the two previous ones.
140 participants will undergo an exhaustive pre- and post-intervention evaluation that includes neuropsychological, neuroimaging, genetic and biochemical analysis before and after the intervention as well as physical and health status assessment.
The present project aims to examine the independent and combined effects of exercise and cognitive stimulation in functional and structural brain plasticity, cognitive performance, emotional state and quality of life, and will determine the demographic and clinical factors that can modulate neuroplasticity. It will allow us to study the neurophysiological mechanisms by which the different types of intervention have an effect on the structure and functioning of the brain and cognition within an omics framework.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Physical exercise (n= 40) | Experimental | Walking program up to 45 minutes, 5 times a week for 3 months. |
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| Cognitive training (n=40) | Experimental | Computerized cognitive training up to 45 minutes, 5 times a week for 3 months. |
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| Combined training (n=40) | Experimental | Exercise and cognitive training up to 90 minutes, 5 times a week for 3 months. |
|
| Control group (n=20) | No Intervention | Waiting list group.They receive no intervention during this waiting period. At the end of this period our training programs are available to them. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical exercise | Behavioral | The structured physical activity plan consists of a walking program with an initial progressive phase (first week: 30 minutes/session and second week: 45 minutes/session, with a Borg scale of perceived exertion between 9 and 10) and an improvement and maintenance phase (10 weeks, 45 minutes/session with a Borg scale of perceived exertion between 11 and 14). |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in functional and structural brain plasticity assessed with Magnetic Resonance Imaging | Resting state connectivity, structural connectivity, white matter integrity, tractography, volume of white and grey matter structures. | Baseline and 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in cognitive function | Tests of executive function, attention, memory, language, visuospatial abilities and speed | Baseline and 3 months |
| Changes in emotional and functional status: Cognitive decline |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in global cognitive function | Mini mental state examination | Baseline and 3 months |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maria Mataro Serrat, Ph.D. | University of Barcelona | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Atenció Primà ria el Maresme | Mataró | Barcelona | 08303 | Spain |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33192485 | Derived | Roig-Coll F, Castells-Sanchez A, Lamonja-Vicente N, Toran-Monserrat P, Pera G, Garcia-Molina A, Tormos JM, Montero-Alia P, Alzamora MT, Dacosta-Aguayo R, Soriano-Raya JJ, Caceres C, Erickson KI, Mataro M. Effects of Aerobic Exercise, Cognitive and Combined Training on Cognition in Physically Inactive Healthy Late-Middle-Aged Adults: The Projecte Moviment Randomized Controlled Trial. Front Aging Neurosci. 2020 Oct 29;12:590168. doi: 10.3389/fnagi.2020.590168. eCollection 2020. | |
| 31481889 |
| Label | URL |
|---|---|
| blog of the project | View source |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D000091942 | Cognitive Training |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Institut Guttmann |
| OTHER |
| Germans Trias i Pujol Hospital | OTHER |
| University of Pittsburgh | OTHER |
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|
| Cognitive training | Behavioral | We use a computerized cognitive training tele-medicine tool, designed by the Guttmann Institute: Guttmann Neuro Personal Trainer (PREVIRNET). Sessions will consist in activities of attention, memory and executive functions, also put in place progressively and parallel to the physical activity. |
|
| Combined training | Behavioral | Subjects included in this group receive both types of intervention. |
|
Short Form of the Informant Questionnaire on Cognitive Decline in the Elderly (Short IQCODE)
| Baseline and 3 months |
| Changes in emotional and functional status: Depression | Geriatric Depression Scale (GDS) | Baseline and 3 months |
| Changes in emotional and functional status: Mood | Adapted Visual Analog Mood Scale (VAMS) | Baseline and 3 months |
| Changes in emotional and functional status: Clinical outcome | Spanish version of the Clinical Outcomes in Routine Evaluation - Outcome Measure (CORE-OM) | Baseline and 3 months |
| Changes in health, fitness and physical activity: Cardiovascular risk factors | Cardiovascular risk factors | Baseline and 3 months |
| Changes in health, fitness and physical activity: Sleep | Pittsburgh Sleep quality Index | Baseline and 3 months |
| Changes in health, fitness and physical activity: Physical activity questionnaire | Spanish version of the reduced Minnesota leisure time physical and activity questionnaire (VREM) | Baseline and 3 months |
| Changes in health, fitness and physical activity: Fitness | One-mile Rockport walk test | Baseline and 3 months |
| Changes in health, fitness and physical activity: Physical activity monitoring | Polar Loop activity monitoring device. | Baseline and 3 months |
| Changes in metabolites and gene expression patterns | Metabolomic and transcriptomic analyses | Baseline and 3 months |
| Derived |
| Castells-Sanchez A, Roig-Coll F, Lamonja-Vicente N, Altes-Magret M, Toran-Monserrat P, Via M, Garcia-Molina A, Tormos JM, Heras A, Alzamora MT, Fores R, Pera G, Dacosta-Aguayo R, Soriano-Raya JJ, Caceres C, Montero-Alia P, Montero-Alia JJ, Jimenez-Gonzalez MM, Hernandez-Perez M, Perera A, Grove GA, Munuera J, Domenech S, Erickson KI, Mataro M. Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol. Front Aging Neurosci. 2019 Aug 14;11:216. doi: 10.3389/fnagi.2019.00216. eCollection 2019. |
| Neuroscience Institute University of Barcelona | View source |
| IDIAP Jordi Gol | View source |
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |