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| Name | Class |
|---|---|
| National Institutes of Health (NIH) | NIH |
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The purpose of this study is to gain a better understanding of the effects of exercise and cognitive training on improving brain function in healthy older adults who may be at risk for developing Alzheimer's Disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise Training | Active Comparator |
| |
| Combined Cognitive/Exercise Training | Active Comparator |
| |
| Cognitive Training | Active Comparator |
| |
| Combined Low Intensity Training | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Training | Other | Aerobic exercise training program designed by the Cardiac Rehabilitation department |
|
| Measure | Description | Time Frame |
|---|---|---|
| Brain activation patterns measured by functional MRI | baseline and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Neuropsychological Testing | baseline and 12 weeks | |
| Exercise assessment | baseline and 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stephen M Rao, Ph.D. | The Cleveland Clinic | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Cleveland Clinic | Cleveland | Ohio | 44195 | United States |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| D000091942 | Cognitive Training |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| Cognitive Training | Other | Based on cognitive training program Brain Fitness® |
|
| Flexibility Training | Other | Non-aerobic flexibility training program designed by the Cardiac Rehabilitation department |
|
| Educational Sessions | Other | DVD-based educational programs on history, art, and literature |
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| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D000066530 | Neurological Rehabilitation |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D006296 | Health Services |
| D005159 | Health Care Facilities Workforce and Services |