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Fluid boluses are often administered with the aim of improving tissue perfusion in critically ill patients. It is unclear whether the temperature of the fluid has an impact on the hemodynamic response. The aim of this study is to describe the hemodynamic effects of a fluid bolus with two different temperatures.
A randomized, controlled, cross-over study in 21 healthy volunteers. The participants will receive a fluid bolus of 500 ml Ringer's Acetate at either 22°C or 38°C over 15 minutes in a randomized order. Non-invasive measures will be made of cardiac index, mean arterial pressure, systolic blood pressure, diastolic blood pressure, heart and pulse rate, saturation and temperature. Hemodynamic measure will be made using the Clearsight® system. Measurements will be made during 120 minutes. The second session will take place at least one day later, and the participant will then receive the other fluid temperature.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Body temperature fluid | Experimental | 500ml Ringers Acetate infused over 15 minutes warmed to 38°C |
|
| Room temperature fluid | Active Comparator | 500ml Ringers Acetate infused over 15 minutes cooled to 22°C |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ringer's Acetate (warm) | Drug | Body temperature fluid |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac index 15 minutes | Change in cardiac index at 15 minutes from start of infusion | 15 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiac index 120 minutes | Change in cardiac index during 120 minutes from start of infusion | 120 minutes |
| Blood pressure 120 minutes | Change in blood pressure during 120 minutes from start of infusion |
| Measure | Description | Time Frame |
|---|---|---|
| Time to return to baseline for CI | Time to return to baseline for CI | 0-120 minutes |
| Time to return to baseline for blood pressure | Time to return to baseline for blood pressure |
Inclusion Criteria:
- Volunteers 18 years or older Previously healthy
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Maria Cronhjort, MD, PhD | Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska Institutet Södersjukhuset | Stockholm | 118 83 | Sweden |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30482135 | Derived | Wall O, Ehrenberg L, Joelsson-Alm E, Martensson J, Bellomo R, Svensen C, Cronhjort M. Haemodynamic effects of cold versus warm fluid bolus in healthy volunteers: a randomised crossover trial. Crit Care Resusc. 2018 Dec;20(4):277-284. |
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| ID | Term |
|---|---|
| D001832 | Body Temperature Changes |
| D020896 | Hypovolemia |
| ID | Term |
|---|---|
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| C028570 | Ringer's acetate |
| D003080 | Cold Temperature |
| ID | Term |
|---|---|
| D013696 | Temperature |
| D013816 | Thermodynamics |
| D055585 | Physical Phenomena |
| D014887 | Weather |
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Crossover study of 2 different temperatures of crystalloid fluid bolus.
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Unblinded (unable to blind subjects)
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| Ringer's Acetate (cold) | Drug | Room temperature fluid |
|
|
| 120 minutes |
| Heart rate 120 minutes | Change in heart rate during 120 minutes from start of infusion | 120 minutes |
| Temperature 120 minutes | Change in body temperature during 120 minutes from start of infusion | 120 minutes |
| 0-120 minutes |
| Time to return to baseline for heart rate | Time to return to baseline for heart rate | 0-120 minutes |
| Time to return to baseline for temperature | Time to return to baseline for temperature | 0-120 minutes |
| D001272 |
| Atmosphere |
| D004777 | Environment |
| D055669 | Ecological and Environmental Phenomena |
| D001686 | Biological Phenomena |
| D008685 | Meteorological Concepts |
| D004778 | Environment and Public Health |