The aim of this study is to investigate the effect of respectively 10 and 22 degrees Celsius Ringer's lactate solution on the physiological response in healthy adults. In a single center crossover study the investigators will include and randomize 25 healthy volunteers to receive 1 liter of Ringer's lactate either cold (10°C, 50°F), or at room temperature (22°C, 71,6°F) with 100 ml/min. Fluids will be administered through a peripheral vein. After a minimum "washout period" of 24 hours, subjects are switched to receive infusion at the other aforementioned temperatures.

The main outcomes of this study are:

Primary:

• The increase in Mean Arterial Pressure (MAP) 30 minutes after started infusion

Secondary:

• Time until return of MAP to baseline value after infusion.
• Changes in Visual Analog Scale (VAS) of discomfort during infusion
• Changes in temperature, blood pressure, heart rate, peripheral oxygen saturation cardiac index, cardiac output, total peripheral resistance index and stroke volume
• Changes in the intravascular volume status and the fluid responsiveness
• Changes in biochemical parameters at baseline, 30 and 60 minutes.
• Changes in Rotational thromboelastometry (ROTEM) analysis at baseline, 30 and 60 minutes

Inclusion Criteria:

• Age between 18-64

Exclusion Criteria:

• Pre-existing medical problems that are contraindicated for cold crystalloid infusions.
• Pregnancy (validated through a certified urine pregnancy test)
• Body mass index >35 kg/m2
• Medication use, including over-the-counter anti-pyretics within 48 hours, with exception of allergy medication and contraceptives.
• Any family history or predisposition of coagulopathies.
• Any intake of inhibitors of 11β-Hydroxysteroid dehydrogenase the past 48 hours (products containing liquorice)