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The present study aims at evaluating the effect of respiratory muscle training in adult patients with cystic fibrosis on lung function, exercise performance and quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Endurance respiratory muscle training | Experimental | The intervention consists in performing isocapnic hyperpnea at 70-80% of maximal voluntary ventilation for 20 min, 5 times a week, for 8 weeks |
|
| Resistance inspiratory muscle training | Active Comparator | The intervention consists in performing inspiratory resistive breathing at 70-80% of maximal inspiratory pressure for 20 min, 5 times a week, for 8 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endurance respiratory muscle training | Other | Training program of the respiratory muscles in endurance by using sustained isocapnic hyperpnea |
|
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory muscle endurance | Total breathing duration (in min) measured during an incremental hyperpnea test | Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1) |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory muscle strength | Peak pressure (in mmHg) during maximal inspiratory and expiratory maneuvers | Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1) |
| Maximal cycling performance |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Hospital | Grenoble | 38000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33331663 | Derived | Stanford G, Ryan H, Solis-Moya A. Respiratory muscle training for cystic fibrosis. Cochrane Database Syst Rev. 2020 Dec 17;12(12):CD006112. doi: 10.1002/14651858.CD006112.pub5. |
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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The patients will be randomized in 2 different groups, one being involved in an endurance respiratory muscle training program, the other being involved in resistance inspiratory muscle training.
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| Resistance inspiratory muscle training | Other | Training program of the inspiratory muscles in resistance by using repeated inspiratory maneuvers against a resistance |
|
Peak maximal power output (in W) during an incremental cycling test
| Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1) |
| Quality of life of patients after the intervention | Score obtained during the questionnaire CQF14+ | Change from baseline (i.e. T0) measured immediately after the 8 weeks of intervention (T1) |
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |
| D001519 | Behavior |