Combined Inspiratory Muscle and 'Whole Muscle' Training in Children With Cystic Fibrosis

To study the effects of an 8-week combined inspiratory muscle training and exercise (resistance+aerobic) program on of a lung volume, inspiratory muscle strength (maximal inspiratory pressure, PImax) and cardiorespiratory fitness (maximal oxygen uptake, VO2peak) (primary outcomes)and dynamic muscle strength, body composition and quality of life (QoL) in children with Cystic Fibrosis (CF) (secondary outcomes).

The investigators hypothesized that the combined training program would significantly benefit most of the aforementioned variables (especially, primary outcomes).

Inclusion Criteria:

• boy/girl aged 6-17 years
• living in the Madrid area

Exclusion Criteria:

• severe lung deterioration [forced expiratory volume (FEV1) <50% of expected]
• unstable clinical condition (hospitalization within the previous 3 months)
• Burkholderia cepacia infection
• any disorder (e.g. muscle-skeletal) impairing exercise.