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Cystic fibrosis is a genetic disease that affects some organs of the human body. Among them, the lungs tend to be the most affected due to the accumulation of mucus in the airways, which in addition to avoiding the passage of air, favors pulmonary infections. With the evolution of the condition, secondary complications arise, such as postural changes, decreased respiratory muscle strength, decreased functional capacity and, consequently, quality of life. Therefore, respiratory muscle training may be an intervention that improves the respiratory condition of these individuals, allowing an improvement in the quality of life and may delay the evolution of respiratory symptoms. Thus, this study aims to investigate a home protocol of respiratory muscle training on respiratory muscle strength, lung function, quality of life, posture and functional capacity in adolescents and adults with cystic fibrosis. The researchers believe that the training can cause an improvement in the studied variables, and can be inserted in the usual treatment of these patients.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| GExp | Experimental | This group will perform the inspiratory muscle training with moderate load |
|
| GCon | Active Comparator | This group will initiate inspiratory muscle training with low load |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Inspiratory muscle training | Device | This group will initiate inspiratory muscle training with 40% of the MIP load and each week will have a load increase of 10% of the initial MIP up to 4 weeks of training |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline Posture at 4 weeks | Inclinometer Danoplus® | Baseline and after 4 weeks of training |
| Change from baseline Health-related quality of life at 4 weeks | Health-related quality of life questionnaire (HRQoL) | Baseline and after 4 weeks of training |
| Measure | Description | Time Frame |
|---|---|---|
| Change from baseline Respiratory muscle strength at 4 weeks | MVD300® | Baseline and after 4 weeks of training |
| Change from baseline Pulmonary function at 4 weeks | Spirometry test using Koko® device |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Victor Oliveira, Master | Universidade Federal do Rio Grande do Norte | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidade Federal do Rio Grande do Norte | Natal | Rio Grande do Norte | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33331663 | Derived | Stanford G, Ryan H, Solis-Moya A. Respiratory muscle training for cystic fibrosis. Cochrane Database Syst Rev. 2020 Dec 17;12(12):CD006112. doi: 10.1002/14651858.CD006112.pub5. |
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| ID | Term |
|---|---|
| D003550 | Cystic Fibrosis |
| ID | Term |
|---|---|
| D010182 | Pancreatic Diseases |
| D004066 | Digestive System Diseases |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| Baseline and after 4 weeks of training |
| Change from baseline Functional capacity at 4 weeks | three-minute step test | Baseline and after 4 weeks of training |
| D030342 |
| Genetic Diseases, Inborn |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| D007232 | Infant, Newborn, Diseases |