Sodium Creatine Phosphate in Heart Valve Surgery

Cardioprotective Effects of Sodium Creatine Phosphate in Valve Surgery: A Prospective Randomized Controlled Study

To explore the effect of intraoperative sodium creatine phosphate on myocardial protection in patients undergoing valve surgery

Objective: To explore the effect of intraoperative sodium creatine phosphate on myocardial protection in patients undergoing valve surgery Methods: 250 patients undergoing valve surgery were randomly divided into experimental group and control group. 5g creatine phosphate was dissolved in 50ml saline solution. After induction of anesthesia, the patients were first given a load dose of 1g, 20min (30ml / h) , And then pumped at a rate of 1 g / h (10 ml / h). The control group was treated with saline in the same manner. The cTnI level was measured at the corresponding time points. Hemodynamic indexes and postoperative complications were recorded.

Inclusion Criteria:

• valvular disease patients requiring valvular replacement or repair surgery with cardiopulmonary bypass(CPB)

Exclusion Criteria:

• thoracoscopic valve surgery
• other organ dysfunction: such as cancer, organ failure, severe anemia, infection
• patients with mental disorders
• coagulopathy, active ulcer, ischemic or hemorrhagic stroke (within 6 months), trauma