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| Name | Class |
|---|---|
| Guangzhou First People's Hospital | OTHER |
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Remote ischaemic preconditioning has shown its cardiac protective effect during heart surgery including coronary artery bypass graft surgery, congenital heart disease and aneurysm. However, no data was reported on heart valve disease surgery. Rheumatic heart disease is one of the major heart diseases requiring surgery in China. Thus, the investigators chose heart valve disease as a focus to see whether remote ischaemic preconditioning also has cardiac protective effect during heart valve surgery.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| treatment | Experimental | remote ischaemic preconditioning |
|
| untreated | No Intervention | control |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| remote ischaemic preconditioning | Procedure | Remote ischaemic preconditioning consisted of three 5-min cycles of right upper arm ischaemia, which was induced by an automated cuff -inflator placed on the right upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated. There was a 5- to 10-min interval between completion of the remote ischaemic preconditioning protocol and initiation of bypass.Control patients had a deflated cuff placed on the right upper arm for 30 min. |
| Measure | Description | Time Frame |
|---|---|---|
| plasma troponin I level | The investigators will measure the plasma troponin I level in several time points before and after surgery in each patient. | with 7 days after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| serum creatinine | within 7 days after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jing-song Ou, MD,PhD | The Frist Affiliated Hospital, Sun Yat-sen University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Guangzhou First Municipal People's Hospital | Guangzhou | Guangdong | 510180 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17707752 | Background | Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, Ashley E, Vichare S, Di Salvo C, Kolvekar S, Hayward M, Keogh B, MacAllister RJ, Yellon DM. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: a randomised controlled trial. Lancet. 2007 Aug 18;370(9587):575-9. doi: 10.1016/S0140-6736(07)61296-3. | |
| 22107759 |
| Label | URL |
|---|---|
| Pubmed | View source |
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| ID | Term |
|---|---|
| D006349 | Heart Valve Diseases |
| D012214 | Rheumatic Heart Disease |
| D016127 | Heart Valve Prolapse |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D012213 | Rheumatic Fever |
| D013290 | Streptococcal Infections |
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|
| Derived |
| Xie JJ, Liao XL, Chen WG, Huang DD, Chang FJ, Chen W, Luo ZL, Wang ZP, Ou JS. Remote ischaemic preconditioning reduces myocardial injury in patients undergoing heart valve surgery: randomised controlled trial. Heart. 2012 Mar;98(5):384-8. doi: 10.1136/heartjnl-2011-300860. Epub 2011 Nov 22. |
| D016908 |
| Gram-Positive Bacterial Infections |
| D001424 | Bacterial Infections |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |