Impact of Perioperative Treatment With Intravenous Glutamine on Myocardial Protection in Cardiac Surgery Patients With Aortic Stenosis

Impact of Perioperative Treatment With Intravenous Glutamine on Myocardial Protection in Cardiac Surgery Patients With Aortic Stenosis

The purpose of this study is to confirm if myocardial protection effect can be obtained by intravenous administration of glutamine in patients undergoing aortic valve replacement with severe aortic stenosis (who are at high risk for ischemia-reperfusion injury). As a prospective double blinded randomized placebo-controlled trial, the investigators detect and compare the degree of myocardial damage(with CK-MB and Troponin T) and myocardial protection (through hsp 70 expression in atrial tissue), cardiovascular index, inflammatory reaction, and clinical manifestation.

Inclusion Criteria:

• Adult patients with between 20 and 80 years scheduled for aortic valve replacement alone or combined surgery including aortic valve replacement due to severe aortic valve stenosis

Exclusion Criteria:

• Patients with renal insufficiency (eGFR 60 ml / min / 1.73 m 2 or less)
• patients who are considering surgery for coronary artery disease or who have a stenosis> 70%
• hemodynamically unstable patients undergoing emergency surgery or patients with intra-aortic balloon pump insertion
• patients unable to make their own decisions, illiterate, foreigners
• epilepsy
• severe metabolic acidosis
• pulmonary edema
• history of myocardial infarction
• elevation of total bilirubin or AST / ALT
• Patients higher than normal, weighing more than 80 kg
• with evidence of infection
• pregnant and lactating women