The Preventive Effects of Sub Hypnotic Dose of Propofol for Nausea and Vomiting Induced by Hemabate

The Preventive Effect of Sub Hypnotic Dose of Propofol for Nausea and Vomiting Induced by Hemabate

This is a randomized, placebo-controlled trail, the objective of this study is observation the effect of sub hypnotic dose of propofol for prevention of nausea and vomiting induced by hemabate during spinal anesthesia for elective cesarean section. The primary outcome is the presence of post-delivery intra-operative nausea and vomiting in parturients. The patients demographic characteristics, blood pressure, sensory block level, and the medications will be collected.

Inclusion Criteria:

• Patients aged 20-40 years;
• American Standards Association status I-II.

Exclusion Criteria:

• Patients with allergy or hypersensitivity to propofol, lipid emulsion, or granisetron;
• History of nausea or vomiting within 24h before cesarean delivery;
• History of gastrointestinal or psychiatric disease, motion sickness, smoking, postoperative nausea and vomiting;
• Morbid obesity;
• Consumption of drugs such as opioids, antiemetics , H2 antagonists, phenothiazines and/or corticosteroids within 24h before the study period;
• Any chronic medical or surgical disorders complicating the pregnancy;
• Conditions contraindicating regional anesthesia.