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The purpose of this study is to clarify whether or not a low-dose propofol infusion can effectively prevent postoperative nausea and vomiting (PONV) in patients who have a documented history of PONV and/or motion sickness.
Propofol is administered as both low dose and as sole anesthetic in patients with history of PONV and/or motion sickness. But efficacy of one dose over the other is not studied. This study plans to clarify if propofol in low dose is as effective as its administration as sole anesthetic in patients with history of PONV and/or motion sickness
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol | Experimental | Low-dose propofol infusion at 25 mcg/kg/min |
|
| Placebo | Placebo Comparator | Same volume of 0.9% normal saline as the study group |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | Propofol is administered starting at surgery induction and ending at skin closure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Nausea (urge to vomit) episodes | Number of self-reported nausea episodes | 24 hours |
| Retching (labored, spasmodic, rhythmic contractions of respiratory muscles without expulsion of gastric contents) episodes | Number of self-reported retching episodes | 24 hours |
| Vomiting (forceful expulsion of gastric contents) episodes | Number of self-reported vomiting episodes | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Choice of antiemetic- Dexamethasone | medication administered. | 24 hours |
| Number of times dexamethasone administered | frequency of administration |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sonal Sharma, MD | Assistant Professor, Department of Anesthesiology and Perioperative Medicine | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Penn State Health Milton S Hershey Medical Center | Hershey | Pennsylvania | 17033 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41593496 | Derived | Keck WL, Deng E, Liu WM, Kanekar R, Lomivorotov V, Sharma S. Effect of low-dose propofol infusion with sevoflurane versus propofol-only total intravenous anesthesia on postoperative nausea and vomiting in high-risk patients: a single-blind randomized controlled clinical trial. BMC Anesthesiol. 2026 Jan 28;26(1):136. doi: 10.1186/s12871-026-03649-7. |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Feb 12, 2026 | Mar 4, 2026 | 4 | ||
| Apr 2, 2026 |
| ID | Term |
|---|---|
| D014839 | Vomiting |
| D009041 | Motion Sickness |
| ID | Term |
|---|---|
| D012817 | Signs and Symptoms, Digestive |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Placebo | Other | Placebo is administered starting at surgery induction and ending at skin closure |
|
| 24 hours |
| Choice of antiemetic- Ondansetron | medication administered. | 24 hours |
| Number of times ondansetron administered | frequency of administration | 24 hours |
| Choice of antiemetic- Promethazine | medication administered | 24 hours |
| Number of times promethazine administered | frequency of administration | 24 hours |
| Choice of antiemetic- metoclopramide | medication administered | 24 hours |
| Number of times metoclopramide administered | frequency of administration | 24 hours |
| Choice of antiemetic- Prochlorperazine | medication administered | 24 hours |
| Number of times prochlorperazine administered | frequency of administration | 24 hours |
| Choice of antiemetic- Droperidol | medication administered | 24 hours |
| Number of times droperidol administered | frequency of administration | 24 hours |
| Choice of antiemetic- scopolamine | medication administered | 24 hours |
| Number of times scopolamine administered | frequency of administration | 24 hours |
| Choice of antiemetic-diphenhydramine | medication administered | 24 hours |
| Number of times diphenhydramine administered | frequency of administration | 24 hours |
| Apr 23, 2026 |
| 5 |
| May 18, 2026 | Jun 11, 2026 | 6 |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |