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Observe effects of oxytocin on individuals with autism spectrum disorder
To observe the effects of oxytocin on individuals with autism spectrum disorder according to gender, in facial recognition and eye tracking tests. The investigators will apply the nepsy and eye tracking tests before and 45 minutes after the puff with oxytocin or placebo at the dose of 0.4 IU / kg / dose maximum of 24 IU. The next week the volunteer will return and will do the same procedure because whoever took the placebo would take oxytocin and vice versa. Is a randomized, double-blind, placebo-controlled clinical trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| oxytocin spray | Experimental | oxytocin nose spray dose 0,4IU/kg, once unique dose |
|
| placebo | Placebo Comparator | saline nose spray, 0,9 %, once unique dose |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Oxytocin | Drug | Single dose oxytocin 45 minutes before the test |
|
| Measure | Description | Time Frame |
|---|---|---|
| Eye tracking | Eye tracking program | on average of 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Nepsy | face recognize | on average of 1 year |
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Inclusion Criteria:Diagnosis of ASD by DSMV
Exclusion Criteria:- pregnant women, infants and
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| Name | Affiliation | Role |
|---|---|---|
| Debora Zambori | Instituto de Psiquiatria | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Instituto de Psiquiatria | São Paulo | 04117-130 | Brazil |
The investigators intend to share research information, such as, harms and benefits
6 months
Clinicians and students
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| ID | Term |
|---|---|
| D001321 | Autistic Disorder |
| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D010121 | Oxytocin |
| ID | Term |
|---|---|
| D010909 | Pituitary Hormones, Posterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
| D006728 | Hormones |
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| placebo | Other | saline solution 0,9% spray nasal |
|
| D006730 |
| Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |