Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions | NCT03146286 | Trialant

CompletedInterventionalNot ApplicableUpdated May 21, 2019

Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions

Overview

Key facts that identify this study and show where it stands today.

ClinicalTrials.gov ID: NCT03146286
Lead Sponsor: University of NottinghamOTHER
Overall Status: Completed
Study Type: Interventional
Phase: Not Applicable
Enrollment: 8Actual
Last Update Posted: May 21, 2019Actual
Start Date: Aug 1, 2015Actual
Primary Completion Date: Dec 3, 2015Actual
Completion Date: Dec 3, 2015Actual

Description

What the study is about and why it is being run, in the researchers' own words.

Official Title: Skeletal Muscle Protein Metabolism and Insulin Sensitivity in Overweight Individuals: Effects of Meals With Various Fatty Acid Compositions
Brief Summary: The aim of the study will investigate whether impairment in the action of insulin to promote the use of glucose in skeletal muscle (insulin resistance) as a result of oral ingestion of a liquid meal rich in saturated fat is linked to reduced ability of muscles to synthesise new protein in response to dietary protein intake, which ultimately may compromise maintenance of muscle size and quality of life and whether partially replacing saturated fat in the liquid meal with omega 3 polyunsaturated FA (n3PUFA) will ameliorate these negative effects.

Conditions

The medical conditions and diseases this study investigates.

Insulin Resistance

Interventions

The treatments and procedures being evaluated in this study.

Saturated fat
Placebo
Fish Oil

Participation

Who can join this study and the criteria used to decide.

Ages Eligible for Study: Adult (18-64)
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: Yes
Eligibility Criteria: Inclusion Criteria:

Male, healthy, overweight (BMI>27 kg/m2 and fat mass >30%) non-diabetic individuals.

Exclusion Criteria:

Diabetes, smoking, cardiovascular disease

Design

How the study is designed and how its participant groups are organized.

Primary Purpose: Basic Science
Allocation: Randomized
Interventional Model: Crossover Assignment
Masking: Single

Contacts

The people to reach with questions about this study or how to join it.

No central contacts

There are no central contacts for this study.

Locations

Where the study is run and whether each site is currently recruiting.

No locations

There are no locations for this study.

Collaborators

The organizations and people involved in this study.

Lead Sponsor: University of NottinghamOTHER

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