Cardiac Resynchronization Therapy in Pulmonary Hypertension

Cardiac Resynchronization Therapy in Pulmonary Hypertension

This study is being conducted to determine whether patients with advanced pulmonary hypertension when treated with cardiac resynchronization therapy improve hemodynamically and/or receive clinical benefit.

This study aims to determine whether stimulating earlier activation of the failing right ventricle in pulmonary hypertension reduces the effects of interventricular dependence in human subjects, thereby improving overall cardiac function and symptoms in patients with pulmonary hypertension and right ventricle failure with NYHA Class 3-4 symptoms.

Inclusion Criteria:

• Pulmonary hypertension, defined as pulmonary artery systolic pressure greater than 40 mm Hg by transthoracic echocardiogram or right heart catheterization
• LVEF ≥ 50%
• Baseline 6MWT distant <400 meters
• Baseline NYHA Functional class ≥ III

Exclusion Criteria:

• LVEF < 50%
• 6MWT duration > 400 meters
• NYHA Functional class < III
• Left bundle branch block
• Non-sinus rhythm
• Severe aortic stenosis (Aortic valve area < 1 cm2)
• Severe mitral regurgitation
• Acute cardiac failure
• Dependency on intravenous inotropies
• Severe obstructive pulmonary disease
• Hypertrophic obstructive cardiomyopathy
• Amyloidosis
• Dependence on pacing