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Pulmonary arterial hypertension is a disease characterised by pathological changes in the pulmonary arteries leading to a progressive increase in pulmonary vascular resistance and pulmonary artery pressure. Right ventricular failure is the main cause of death in patients with pulmonary arterial hypertension, and the ability of the right ventricle to adapt to the progressive increase in pulmonary vascular resistance associated with changes to the pulmonary vasculature in pulmonary arterial hypertension is the main determinant of a patient's functional capacity and survival.
Right ventricular dyssynchrony was present in a substantial proportion of patients with pulmonary arterial hypertension and this dyssynchrony adversely affected right ventricular function.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hemodynamic study, cardiac pacing | Experimental | We propose to study the hemodynamic response to a temporary atrio-dual right ventricular stimulation in pulmonary arterial hypertension subjects.Patients will be is own comparator. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resynchronization therapy of right ventricle | Procedure | Right atrio-ventricular resynchronization therapy combined with right intra-ventricular resynchronization therapy |
|
| Measure | Description | Time Frame |
|---|---|---|
| cardiac index measured during right catheterization | After two minutes of right stimulation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Paul-Ursmar Milliez, MD, PhD | Contact | +33231065118 | milliez-p@chu-caen.fr |
| Name | Affiliation | Role |
|---|---|---|
| Paul-Ursmar Milliez | Caen UH | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Caen UH | Recruiting | Caen | Basse-Normandie | 14000 | France |
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| ID | Term |
|---|---|
| D000081029 | Pulmonary Arterial Hypertension |
| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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