The aim of the study is to compare different devices available to measure fractional flow reserve (FFR) in coronary arteries.

The decision to perform a percutaneous coronary intervention (PCI) is usually based on angiographic results alone. Angiography can be used for the visual evaluation of the inner diameter of a vessel. Visual evaluation is limited by inter-individual variability.

Fractional flow reserve provides a functional evaluation, by measuring the pressure decline caused by a vessel narrowing.

The original studies validating the use of FFR were conducted with only one device (St-Jude Medical®). Recently, new FFR devices have been commercialized but have not yet been compared.

Inclusion Criteria:

• Patients hospitalized at Caen University Hospital for coronary angiography
• Coronary stenosis needing FFR evaluation according to recommendations
• More than 18 years old
• Clinically stable
• De novo coronary stenosis
• Affiliated to social security
• Informed consent signed

Exclusion Criteria:

• Unstable patients defined by acute coronary syndrome < 7 days
• Contre-indication to adenosine administration (asthma, allergy, high grade atrio-ventricular bloc without pace maker)
• History of coronary artery bypass
• intra-stent restenosis
• Patient not capable of understanding the study
• Informed consent not signed

Consecutifs patients hospitalized for coronary angiography and presenting one or several coronary stenosis needing FFR evaluation