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| Name | Class |
|---|---|
| Golden Jubilee National Hospital | OTHER_GOV |
| Catharina Ziekenhuis Eindhoven | OTHER |
| Onze Lieve Vrouw Hospital | OTHER |
| Stockholm South General Hospital |
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Comparison of Fractional Flow Reserve versus instant Wave-Free Ratio for assessment of coronary artery stenosis severity in routine practice
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FFR; iFR | Interventional Cardiology, Pressure wire, fractional flow reserve, coronary flow measurement |
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| Measure | Description | Time Frame |
|---|---|---|
| Comparison of Fractional Flow Reserve vs. instant Wave-Free Ratio for assessment of coronary artery stenosis severity in routine practice | In this prospective, multicenter, international investigation, all consecutive patients in 5 centers, referred for PCI will be included. FFR will be submitted for one vessel in each patient - this will be the first vessel in which the FFR is performed. Measurements will be performed in duplicate. iFR will be calculated for all lesions for which an FFR measurement is submitted. In addition, iFR and FFR will be compared retrospectively in 1000 patients who had FFR measurements in the recent past | 30 days |
| Measure | Description | Time Frame |
|---|---|---|
| iFR at rest vs iFr during hyperemia | iFR is said to be independent of hyperemia. Accordingly a secondary outcome of this study will be a paired comparison of iFR at rest vs iFr with adenosine induced hyperemia. | 30 days |
| Repeatability of iFr and FFR |
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Inclusion Criteria:
Exclusion Criteria:
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The aim of the present study is to strengthen the results of retrospective comparisons of iFR with FFR by conducting a prospective study in 200 consecutive, unselected patients from 5 different centers.
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| Name | Affiliation | Role |
|---|---|---|
| Prof Keith G. Oldroyd | Golden Jubilee National Hospital | Principal Investigator |
| Prof Colin Berry, MD | Golden Jubilee National Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Stanford | California | United States | |||
| Cardiovascular Center Aalst |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23395076 | Derived | Berry C, van 't Veer M, Witt N, Kala P, Bocek O, Pyxaras SA, McClure JD, Fearon WF, Barbato E, Tonino PA, De Bruyne B, Pijls NH, Oldroyd KG. VERIFY (VERification of Instantaneous Wave-Free Ratio and Fractional Flow Reserve for the Assessment of Coronary Artery Stenosis Severity in EverydaY Practice): a multicenter study in consecutive patients. J Am Coll Cardiol. 2013 Apr 2;61(13):1421-7. doi: 10.1016/j.jacc.2012.09.065. Epub 2013 Feb 6. |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D058226 | Plaque, Atherosclerotic |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| OTHER |
| Brno University Hospital | OTHER |
| Stanford University | OTHER |
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To test repeatability of iFR and FFR
| 30 days |
| Aalst |
| Belgium |
| University Hospital Brno | Brno | Czechia |
| Catharina Ziekenhuis | Eindhoven | Netherlands |
| Stockholm South Hospital | Stockholm | Sweden |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |