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To investigate the impact of consuming dairy yogurt on immun function including natural killer (NK) cell activity, circulating levels of cytokines, and immunoglobulin (Ig) in elderly.
A randomized, open-labelled, placebo-controlled study was conducted on 200 nondiabetic, nonobese and elderly (≥60 years) subjects. Over a twelve-week period, the test group consumed one bottle (120 mL) of dairy yogurt each day, whereas the placebo group consumed same volume of low fat milk daily. NK cell activity (%) was measured based on the ratios of effector cells (E; peripheral blood mononuclear cells, PBMCs) from each participant to target cells (T; K562 cells) at E:T= 10:1, 5:1, 2.5:1, 1.25:1 or 0.625:1. In addition, cytokines and immunoglobulin levels measured using commercial kits as manufacturer's instruction.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Test group | Experimental | Probiotic yogurt supplementation |
|
| Placebo group | Placebo Comparator | Placebo supplementation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Probiotic yogurt | Dietary Supplement | 120 mL of Yogurt containing Lactobacillus delbrueckii subsp. bulgaricus, Streptococcus thermophilus, Lactobacillus casei, Bifidobacterium animalis ssp. lactis, and Lactobacillus plantarum |
| Measure | Description | Time Frame |
|---|---|---|
| Natural killer cell activity | At baseline | |
| Natural killer cell activity | At 12-week follow-up | |
| Change from baseline natural killer cell activity at 12-week | At baseline and 12-week follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| White blood cell | At baseline | |
| White blood cell | At 12-week follow-up | |
| Change from baseline white blood cell at 12-week |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jong Ho Lee | Yonsei University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yonsei University | Seoul | 03722 | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28561762 | Derived | Lee A, Lee YJ, Yoo HJ, Kim M, Chang Y, Lee DS, Lee JH. Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity. Nutrients. 2017 May 31;9(6):558. doi: 10.3390/nu9060558. |
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| ID | Term |
|---|---|
| D007153 | Immunologic Deficiency Syndromes |
| ID | Term |
|---|---|
| D007154 | Immune System Diseases |
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| Placebo | Dietary Supplement | 120 mL of low-fat milk |
|
| At baseline and 12-week follow-up |
| Interleukin-12 | At baseline |
| Interleukin-12 | At 12-week follow-up |
| Change from baseline Interleukin-12 at 12-week | At baseline and 12-week follow-up |
| Interferon-gamma | At baseline |
| Interferon-gamma | At 12-week follow-up |
| Change from baseline Interferon-gamma at 12-week | At baseline and 12-week follow-up |
| Immunoglobulin | At baseline |
| Immunoglobulin | At 12-week follow-up |
| Change from baseline immunoglobulin at 12-week | At baseline and 12-week follow-up |