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Effect of Preoperative Aspirin in patients undergoing Off-pump Coronary Artery Bypass Grafting. A double-blind, placebo-controlled, randomized trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Aspirin group | Active Comparator | a 75 mg uncoated aspirin is administered 2 hours prior to OPCAB |
|
| Placebo group | Placebo Comparator | 75 mg Vit. C is administered 2 hours prior OPCAB |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aspirin | Drug | preoperative uncoated 75 mg Aspirin is administered 2 hours prior OPCAB |
|
| Measure | Description | Time Frame |
|---|---|---|
| Myocardial Injury | Myocardial injury detected by Troponin T (ng/ml) | 6 hours following OPCAB |
| Myocardial Injury | Myocardial injury detected by Troponin T (ng/ml) | 12 hours following OPCAB |
| Myocardial Injury | Myocardial injury detected by Troponin T (ng/ml) | 24 hours following OPCAB |
| Myocardial Injury | Myocardial injury detected by Troponin T (ng/ml) | 72 hours following OPCAB |
| Inflammation | Inflammation detected by CRP (mg/l) | 6 hours following OPCAB |
| Inflammation | Inflammation detected by CRP (mg/l) | 12 hours following OPCAB |
| Inflammation | Inflammation detected by CRP (mg/l) | 24 hours following OPCAB |
| Inflammation | Inflammation detected by CRP (mg/l) | 72 hours following OPCAB |
| Kidney Injury |
| Measure | Description | Time Frame |
|---|---|---|
| Postoperative drainage (ml) | 12 hours and 24 hours following OPCAB | |
| Bleeding complication | reoperation for bleeding, cardiac tamponade | < 30 days following OPCAB |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medinet Heart Centre | Nowa Sól | Lubusz Voivodeship | 67-100 | Poland |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| D001205 | Ascorbic Acid |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
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| vitamin C | Drug | preoperative 75 mg Vit. C (Placebo) is administered 2 hours prior OPCAB |
|
Kidney injury detected by creatinine (mg/dl)
| 6 hours following OPCAB |
| Kidney Injury | Kidney injury detected by creatinine (mg/dl) | 12 hours following OPCAB |
| Kidney Injury | Kidney injury detected by creatinine (mg/dl) | 24 hours following OPCAB |
| Kidney Injury | Kidney injury detected by creatinine (mg/dl) | 72 hours following OPCAB |
| All-cause mortality or MACE up to 30 days after surgery | 30 days after surgery |
| Myocardial Injury | Myocardial injury detected by CK-MB (U/l) | 6 hours following OPCAB |
| Myocardial Injury | Myocardial injury detected by CK-MB (U/l) | 12 hours following OPCAB |
| Myocardial Injury | Myocardial injury detected by CK-MB (U/l) | 24 hours following OPCAB |
| Myocardial Injury | Myocardial injury detected by CK-MB (U/l) | 72 hours following OPCAB |
| Blood transfusions (units) | < 30 days following OPCAB |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |
| D013400 | Sugar Acids |
| D000144 | Acids, Acyclic |
| D002264 | Carboxylic Acids |
| D006880 | Hydroxy Acids |
| D002241 | Carbohydrates |