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Platelet activation after off pump coronary artery bypass (OPCAB) surgery may affect thrombus formation. The purpose of this study is to assess the effects of preoperative continuation of aspirin on platelet activation after off pump coronary artery bypass surgery.
Patients undergoing OPCAB surgery will be randomized to continue preoperative aspirin or discontinue aspirin before surgery.
Platelet activation can be evaluated by measuring platelet p-selectin using flowcytometry. In this study, we will compare platelet-activated markers and conventional coagulation tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| aspirin continuation | Experimental | Intervention : Low-dose aspirin (< 100mg/day) is used before OPCAB surgery in the aspirin continuation group. |
|
| aspirin discontinuation | Experimental | Intervention: Low-dose aspirin is stopped more than 4 days before OPCAB surgery in the aspirin discontinuation group. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| aspirin continuation | Drug | Patients are randomized to continue aspirin before OPCAB surgery. |
|
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in platelet p-selectin at 48 hours after operation | Primary outcome is expression of platelet p-selectin measured by flowcytometry 48 hours after OPCAB surgery in both groups. | after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in conventional coagulation tests at the time of end of operation, 24 hour after operation, and 48hr after operation | prothrombin time (international normalized ratio), activated partial thromboplastin time, fibrinogen | after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in platelet aggregation at the time of end of operation, 24 hour after operation, and 48hr after operation | prediction for stratification of bleeding risk due to antiplatelet agent using multiplate | after induction of anesthesia(baseline), at the time of end of operation, 24 hour after operation, 48hr after operation |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yunseok Jeon, MD, PhD | Seoul National University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001241 | Aspirin |
| ID | Term |
|---|---|
| D012459 | Salicylates |
| D062385 | Hydroxybenzoates |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
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| aspirin discontinuation | Drug | Patients are randomized to discontinue aspirin more than 4 days before OPCAB surgery. |
|
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D006841 |
| Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D006838 | Hydrocarbons |
| D009930 | Organic Chemicals |