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| Name | Class |
|---|---|
| University of Copenhagen | OTHER |
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After gastric sleeve patients undergo a substantial weight loss, but the physiological mechanisms behind the weight loss is not fully elucidated. Studies suggest that gut-hormone secretion is altered comparable to what is also seen after Roux-en-Y gastric bypass, however to which extent is not fully established and furthermore, the mechanisms behind an altered secretion are unclear. The purpose of this study is to investigate absorption and postprandial metabolism of glucose and protein in addition to gut hormonal responses after gastric sleeve compared with a group of un-operated subjects machted on sex, age and BMI. Furter, a group of Roux-en-Y gastric bypass operated patients matched on pre-operative BMI, current BMI, sex and age will be included for comparison.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gastric sleeve operated subjects | 12 patients who have undergone gastric sleeve operation >12 month prior to inclution. |
| |
| Control Subjects | 12 Healthy un-operated control subjects matched to the gastric sleeve group in a one to one manner with respect to BMI, sex and age |
| |
| Gastric bypass operated subjects | 12 patients, who have undergone Roux-en-Y gastric bypass >12 month prior to inclution, matched to the gastric sleeve group in a one to one manner with respect to pre-operative BMI, post-operative BMI, sex and age. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mixed meal test with double tracer technique | Diagnostic Test |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose absorption | Between groups difference in peak Rate of appearance (Ra) of oral glucose tracer SG vs. CON | 0 - 360 minutes |
| Protein absorption | Between groups difference in peak Ra of oral aminoacid tracer SG vs. CON | 0 - 360 minutes |
| Measure | Description | Time Frame |
|---|---|---|
| Glucose absorption | Between group difference in peak Ra of oral glucose comparing SG vs. RYGB | 0 - 360 minutes |
| Protein absorption | Between groups differences in peak Ra of oral aminoacid tracer comparing SG vs. RYGB |
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SG ang RYGB group:
Inclusion Criteria:
Exclusion Criteria:
Un-operated control group:
Inclusion Criteria:
Exclusion Criteria:
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Patients, who have undergone Roux-en-Y gastric bypass OR gastric sleeve operation > 12 month prior to inclusion.
Matched un-operated control subjects.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hvidovre University Hospital | Hvidovre | Please Select | 2650 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30742833 | Derived | Svane MS, Bojsen-Moller KN, Martinussen C, Dirksen C, Madsen JL, Reitelseder S, Holm L, Rehfeld JF, Kristiansen VB, van Hall G, Holst JJ, Madsbad S. Postprandial Nutrient Handling and Gastrointestinal Hormone Secretion After Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy. Gastroenterology. 2019 May;156(6):1627-1641.e1. doi: 10.1053/j.gastro.2019.01.262. Epub 2019 Feb 8. |
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| ID | Term |
|---|---|
| D009767 | Obesity, Morbid |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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Blood and urine samples during mixed meal test with double tracer tecnique using iv tracers ([D2] Phenylalanine, [ring-D4]Tyrosine, [6,6-2H2]Glucose, [1,1,2,3,3-2H5]Glycerol, [15N2]Urea and labelled oral tracers ([U13C6]glucose, intrinsically [ring-D5]Phenylalanine).
| 0 - 360 minutes |
| Glucose kinetics | Between groups differences in AUC Ra of oral glucose tracer | 0 - 360 minutes |
| Protein kinetics | Between groups differences in AUC Ra of oral aminoacid tracer | 0 - 360 minutes |
| Insulin secretion | Between groups differences in iAUC of serum insulin and C-peptide | 0 - 240 minutes |
| Glucagon-like Peptide 1 (GLP-1) secretion | Between groups differences in iAUC of plasma concentration of GLP-1 | 0 - 240 minutes |
| Glucose-dependent Insulinotropic Peptide (GIP) | Between groups differences in iAUC of plasma concentration of GIP | 0 - 240 minutes |
| Ghrelin secretion | Between groups differences in iAUC of plasma concentration of ghrelin | 0 - 240 minutes |
| Glucagon secretion | Between groups differences in iAUC of plasma cncentration of glucagon | 0-240 minutes |
| Peptide YY | Between groups differences in iAUC of plasma concentration of PYY | 0-240 minutes |
| Endogenous glucose production | Calculated via double tracer tecnique both in the fasting and post prandial state. | -120 - 360 minutes |
| Lipolysis | Between groups differences in Rate of Disappearance of glycerol tracer. | -120 - 360 |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |