Comparison of Gastric Bypass and Sleeve Gastrectomy in Metabolic and Cardiovascular Indices

A Comparative Study of the Effects of Roux en Y Gastric Bypass and Sleeve Gastrectomy on Postprandial Gut Hormone Responses, Glycemia and Lipid Profile, Weight Loss, and Indices of Cardiovascular Risk

Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery. On each occasion, anthropometric data were collected, resting metabolic rate was measured, and the patients underwent a panel of cardiovascular examinations (heart rate variability, baroreflex sensitivity, heart ultrasound). Following that, they consumed a test meal and completed visual analog scales for the subjective assessment of hunger and fullness every 30 minutes for 3 hours. At the same time points, blood samples were collected for the consequent measurement of glucose, insulin, lipids, and gastrointestinal hormones.

Inclusion Criteria:

• BMI >40 kg/m2
• Age between 18 and 65 years
• Proven failure to lose weight through non-surgical interventions

Exclusion Criteria:

• Serious and life threatening comorbidities (renal, cardiac, liver failure, or malignancy)
• Patients' inability to adhere to postsurgical instructions
• Alcohol or other substance abuse
• Concurrent psychiatric illness