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| Name | Class |
|---|---|
| Beth Israel Deaconess Medical Center | OTHER |
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Morbidly obese patients undergoing either Roux en Y gastric bypass or sleeve gastrectomy were examined preoperatively, 3, 6, and 12 months after surgery. On each occasion, anthropometric data were collected, resting metabolic rate was measured, and the patients underwent a panel of cardiovascular examinations (heart rate variability, baroreflex sensitivity, heart ultrasound). Following that, they consumed a test meal and completed visual analog scales for the subjective assessment of hunger and fullness every 30 minutes for 3 hours. At the same time points, blood samples were collected for the consequent measurement of glucose, insulin, lipids, and gastrointestinal hormones.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gastric bypass bariatric surgery | Active Comparator | Patients in this arm underwent Roux-en-Y gastric bypass bariatric surgery for the treatment of morbid obesity |
|
| Sleeve gastrectomy bariatric surgery | Active Comparator | Patients in this arm underwent sleeve gastrectomy bariatric surgery for the treatment of morbid obesity |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Bariatric surgery | Procedure | Bariatric surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in postprandial ghrelin responses | Change in the cumulative postprandial response for ghrelin | 3, 6, and 12 months |
| Change in postprandial GLP-1 responses | Change in the cumulative postprandial response for GLP-1 | 3, 6, and 12 months |
| Change in postprandial PYY responses | Change in the cumulative postprandial response for PYY | 3, 6, and 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in weight | Change in weight (percentage of weight lost through each procedure) | 3, 6, and 12 months |
| Change in postprandial glycemia | Change in the cumulative postprandial response for glucose |
| Measure | Description | Time Frame |
|---|---|---|
| Change in baroreflex sensitivity | Changes in baroreflex sensitivity | 3, 6, and 12 months |
| Change in heart rate variability | Changes in heart rate variability |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexandros Kokkinos, MD, PhD | First Department of Propaedeutic Medicine, NKUA | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27313194 | Background | Holst JJ, Madsbad S. Mechanisms of surgical control of type 2 diabetes: GLP-1 is key factor. Surg Obes Relat Dis. 2016 Jul;12(6):1236-42. doi: 10.1016/j.soard.2016.02.033. Epub 2016 Mar 3. | |
| 17936091 | Background | Korner J, Bessler M, Inabnet W, Taveras C, Holst JJ. Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding. Surg Obes Relat Dis. 2007 Nov-Dec;3(6):597-601. doi: 10.1016/j.soard.2007.08.004. Epub 2007 Oct 23. |
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| ID | Term |
|---|---|
| D009767 | Obesity, Morbid |
| D015431 | Weight Loss |
| ID | Term |
|---|---|
| D009765 | Obesity |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
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| ID | Term |
|---|---|
| D050110 | Bariatric Surgery |
| ID | Term |
|---|---|
| D049088 | Bariatrics |
| D000073319 | Obesity Management |
| D013812 | Therapeutics |
| D013514 | Surgical Procedures, Operative |
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| 3, 6, and 12 months |
| Change in postprandial insulinemia | Change in the cumulative postprandial response for insulin | 3, 6, and 12 months |
| Change in postprandial triglyceridemia | Change in the cumulative postprandial response for triglycerides | 3, 6, and 12 months |
| 3, 6, and 12 months |
| Change in aortic distensibility | Changes in aortic distensibility | 3, 6, and 12 months |
| Change in Tei index | Changes in echocardiographic Tei index | 3, 6, and 12 months |
| 28780756 | Background | Dimitriadis GK, Randeva MS, Miras AD. Potential Hormone Mechanisms of Bariatric Surgery. Curr Obes Rep. 2017 Sep;6(3):253-265. doi: 10.1007/s13679-017-0276-5. |
| 20501690 | Background | Laferrere B, Swerdlow N, Bawa B, Arias S, Bose M, Olivan B, Teixeira J, McGinty J, Rother KI. Rise of oxyntomodulin in response to oral glucose after gastric bypass surgery in patients with type 2 diabetes. J Clin Endocrinol Metab. 2010 Aug;95(8):4072-6. doi: 10.1210/jc.2009-2767. Epub 2010 May 25. |
| 23996294 | Background | Yousseif A, Emmanuel J, Karra E, Millet Q, Elkalaawy M, Jenkinson AD, Hashemi M, Adamo M, Finer N, Fiennes AG, Withers DJ, Batterham RL. Differential effects of laparoscopic sleeve gastrectomy and laparoscopic gastric bypass on appetite, circulating acyl-ghrelin, peptide YY3-36 and active GLP-1 levels in non-diabetic humans. Obes Surg. 2014 Feb;24(2):241-52. doi: 10.1007/s11695-013-1066-0. |
| 27465935 | Background | Farey JE, Preda TC, Fisher OM, Levert-Mignon AJ, Stewart RL, Karsten E, Herbert BR, Swarbrick MM, Lord RV. Effect of Laparoscopic Sleeve Gastrectomy on Fasting Gastrointestinal, Pancreatic, and Adipose-Derived Hormones and on Non-Esterified Fatty Acids. Obes Surg. 2017 Feb;27(2):399-407. doi: 10.1007/s11695-016-2302-1. |
| 36375643 | Derived | Angelidi AM, Kokkinos A, Sanoudou D, Connelly MA, Alexandrou A, Mingrone G, Mantzoros CS. Early metabolomic, lipid and lipoprotein changes in response to medical and surgical therapeutic approaches to obesity. Metabolism. 2023 Jan;138:155346. doi: 10.1016/j.metabol.2022.155346. Epub 2022 Nov 12. |
| D009750 |
| Nutritional and Metabolic Diseases |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D001836 | Body Weight Changes |