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Changes in renal function and body composition in patients with pulmonary hypertension
This prospective single-center study is designed to analyze changes in renal function and body composition in patients with suspected or pre-diagnosed pulmonary hypertension at pulmonary hypertension outpatient clinic, University Hospital Giessen and Marburg, Campus Giessen.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pulmonary Hypertension | Adult outpatients with suspected or prediagnosed pulmonary hypertension irrespective of subclass and all chronic kidney disease stages |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention | Diagnostic Test | No intervention |
|
| Measure | Description | Time Frame |
|---|---|---|
| Changes in renal function in patients with pulmonary hypertension | Estimated GFR based on Chronic Kidney Disease Epidemiology Collaboration-creatinine-cystatin C will be used to determine renal function at baseline and at 1 year follow-up | 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in hydration status in patients with pulmonary hypertension | Bioimpedance analysis will be used to determine hydration status at baseline and at 1 year follow-up | 1 year |
| Changes in nutritional status in patients with pulmonary hypertension |
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Inclusion Criteria:
Exclusion Criteria:
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All patients with suspected or pre-diagnosed pulmonary hypertension at pulmonary hypertension outpatient clinic, University Hospital Giessen and Marburg, Campus Giessen
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| Name | Affiliation | Role |
|---|---|---|
| Werner Seeger, MD | Department of Internal Medicine II, Division of Pulmonology, Nephrology and Critical Care Medicine | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Clinic Giessen and Marburg - Campus Giessen | Giessen | Hesse | 35392 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 20428001 | Background | Bellomo R, Prowle JR, Echeverri JE. Diuretic therapy in fluid-overloaded and heart failure patients. Contrib Nephrol. 2010;164:153-163. doi: 10.1159/000313728. Epub 2010 Apr 20. | |
| 25762355 | Background | Ronco C, Verger C, Crepaldi C, Pham J, De Los Rios T, Gauly A, Wabel P, Van Biesen W; IPOD-PD Study Group. Baseline hydration status in incident peritoneal dialysis patients: the initiative of patient outcomes in dialysis (IPOD-PD study)dagger. Nephrol Dial Transplant. 2015 May;30(5):849-58. doi: 10.1093/ndt/gfv013. Epub 2015 Mar 11. |
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All IPD that underlie results in a publication
Starting 6 months after publication
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| ID | Term |
|---|---|
| D006976 | Hypertension, Pulmonary |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D006973 | Hypertension |
| D014652 | Vascular Diseases |
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Collection of only residual material (blood, urine) for Deutsche Zentrum für Lungenforschung Biobank.
Bioimpedance analysis will be used to determine lean tissue and fat mass at baseline and at 1 year follow-up
| 1 year |
| Prognostic value of baseline renal function, hydration and nutritional status on pulmonary hypertension-associated morbidity and mortality | pulmonary hypertension-associated morbidity and mortality (defined as escalation of pulmonary hypertension-specific therapy, unscheduled hospitalization and all-cause mortality) will be prospectively assessed during follow-up period | 1 year |
| 24578332 | Result | Navaneethan SD, Wehbe E, Heresi GA, Gaur V, Minai OA, Arrigain S, Nally JV Jr, Schold JD, Rahman M, Dweik RA. Presence and outcomes of kidney disease in patients with pulmonary hypertension. Clin J Am Soc Nephrol. 2014 May;9(5):855-63. doi: 10.2215/CJN.10191013. Epub 2014 Feb 27. |
| 19215832 | Result | Damman K, van Deursen VM, Navis G, Voors AA, van Veldhuisen DJ, Hillege HL. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J Am Coll Cardiol. 2009 Feb 17;53(7):582-588. doi: 10.1016/j.jacc.2008.08.080. |
| D002318 |
| Cardiovascular Diseases |