Kidney Disease and Pulmonary Hypertension

Prevalence and Predictors of Kidney Disease, and Long-Term Renal Outcome in Pulmonary Hypertension

Evaluation of the prevalence of kidney disease, hemodynamic predictors and long-term renal outcome in patients with invasively diagnosed pulmonary hypertension.

This study aims to determine the prevalence of kidney disease, hemodynamic predictors and long-term renal outcome of in-hospital patients with invasively diagnosed pulmonary hypertension at the Department of Pulmonology, University Hospital Giessen and Marburg, Giessen, Germany between 1999 and 2016.

Inclusion Criteria:

• older than 18 years
• subjects with invasively diagnosed pulmonary hypertension at rest and available renal function and spot urine data at day of right heart catheterization between March 1999 and December 2016 at the Department of Pulmonology, University Hospital Giessen and Marburg, Giessen, Germany

Exclusion Criteria:

• subjects with estimated GFR <15ml/min/1.73m2 or prior dialysis
• pre-existing acute kidney injury
• non-end stage renal disease with extracorporeal or peritoneal ultrafiltration due to diuretic-resistant fluid overload
• primary kidney disease requiring active immunosuppression
• autosomal dominant polycystic kidney disease
• if subjects are pregnant
• if subjects are recipients of solid-organ transplants
• subjects with pulmonary hypertension with unclear/multifactorial mechanisms (WHO group 5 pulmonary hypertension)