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This study aims to determine the extent to which pre-existing long-term conditions are associated with survival following a heart attack (acute myocardial infarction) using observational data from the UK's national heart attack register.
Using observational data from the Myocardial Ischaemia National Audit Project (MINAP) of all hospitalisations for acute myocardial infarction in all acute hospitals in England and Wales, this study aims to determine the extent to which pre-existing long-term conditions are associated with survival following acute myocardial infarction. The study will include an investigation of individual long term conditions for patients with acute myocardial infarction, including chronic heart failure, cerebrovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic renal failure or peripheral vascular disease as well as the combination of such conditions and their resulting impact on long term all-cause mortality (up to 8.4 years). In addition, an investigation of the association of receipt of guideline recommended care for acute myocardial infarction patients with pre-existing long term conditions will be made.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| long term conditions | Other | Long term conditions including diabetes mellitus, chronic obstructive pulmonary disease or asthma, chronic heart failure, chronic renal failure, cerebrovascular disease or peripheral vascular disease. |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients who died from any cause by the end of the study censoring period | Death data was obtained from national death records from the Office for National Statistics | 8.4 years |
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients who received guideline recommended therapy during the study period | All guideline recommended therapies for acute myocardial infarction relevant to the duration of the study period (2003 to 2013) will be assessed. | Any guideline therapy administered during the patients hospital admission for acute myocardial infarction, an average of 4 days |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with ST-segment elevation myocardial infarction (STEMI) or non-STEMI (NSTEMI) admitted to one of 247 hospitals in England and Wales between 1st January 2003 and 30th June 2013
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| Name | Affiliation | Role |
|---|---|---|
| Chris Gale, PhD, FRCP | University of Leeds | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29509764 | Derived | Hall M, Dondo TB, Yan AT, Mamas MA, Timmis AD, Deanfield JE, Jernberg T, Hemingway H, Fox KAA, Gale CP. Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort. PLoS Med. 2018 Mar 6;15(3):e1002501. doi: 10.1371/journal.pmed.1002501. eCollection 2018 Mar. |
| Label | URL |
|---|---|
| Principal Researchers Profile Page | View source |
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| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D016491 | Peripheral Vascular Diseases |
| D002561 | Cerebrovascular Disorders |
| D007676 | Kidney Failure, Chronic |
| D029424 | Pulmonary Disease, Chronic Obstructive |
| ID | Term |
|---|---|
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D051436 | Renal Insufficiency, Chronic |
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D008173 | Lung Diseases, Obstructive |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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