Skeletal Muscle Energy Metabolism in Women With Weight Lo... | NCT03027479

NCT03027479

Protocol Section

Identification Module

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

ID	Type	Description	Link
2016-A01323-48	Registry Identifier	IdRCB
2016-R27	Other Identifier	CPP

Status Module

Name	Class
Inserm U1069 - Team Nutrition, Growth and Cancer	UNKNOWN

Oversight Module

Design Module

Interventional Study Design

Biospecimen

No data available

No data is available for this block.

Arms/Interventions Module

Arm Groups

Label	Type	Description	Intervention Names
Case group	Experimental	women with ovarian and/or endometrial cancer and weight loss will have muscle, adipose tissue, ovarian tumor and blood samples	Other: Samples
Control group	Other	women scheduled for an intervention for benign ovarian/ endometrial disease and no weight loss will have muscle, adipose tissue and blood samples	Other: Samples

Name	Type	Description	Arm Group Labels	Other Names
Samples	Other	Blood samples, muscle biopsy, adipose tissue samples and ovarian cancer tumor sample	Case group Control group

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Measurement of muscle mitochondrial bioenergetics according to BMI	Measurement of muscle mitochondrial bioenergetics by high resolution oxygraphy	muscle biopsy realized during surgery

Secondary Outcomes

Measure	Description	Time Frame
on muscle biopsy	Quantification of lipids on electron microscope Type of muscular fibers Analyze of gene expression and proteins involved in 1/ Mitochondrial metabolism 2/ lipid metabolism and 3/ muscular proteolysis by RTqPCR with SyBR Green and Western Blot	muscle biopsy realized during surgery

Eligibility Module

Contacts/Locations Module

Name	Affiliation	Role
Lobna OULDAMER, MD, PhD	University Teaching Hospital of Tours	Principal Investigator

Facility	Status	City	State	ZIP	Country	Contacts
Gynecology Department, University Teaching Hospital, Tours		Tours		37044	France

References Module

Citations

PubMed Identifier	Type	Citation	Retractions
36675280	Result	Salaun H, Poisson M, Dolly A, Arbion F, Servais S, Dumas JF, Goupille C, Ouldamer L. Total Polyunsaturated Fatty Acid Level in Abdominal Adipose Tissue as an Independent Predictor of Recurrence-Free Survival in Women with Ovarian Cancer. Int J Mol Sci. 2023 Jan 16;24(2):1768. doi: 10.3390/ijms24021768.

IPD Sharing Statement Module

Condition Browse Module

ID	Term
D001836	Body Weight Changes
D001835	Body Weight
D012816	Signs and Symptoms
D013568	Pathological Conditions, Signs and Symptoms

Intervention Browse Module

ID	Term
D016020	Epidemiologic Study Characteristics
D004812	Epidemiologic Methods
D008919	Investigative Techniques
D017531	Health Care Evaluation Mechanisms