Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| 2015-A00683-46 | Registry Identifier | IdRCB | |
| 2015-R25 | Other Identifier | CPP | |
| 150963B-12 | Other Identifier | ANSM |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Inserm U1069 - Team Nutrition, Growth and Cancer | UNKNOWN |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Undernutrition associated with cancer, or cancer cachexia results from a deterioration of the energy balance that leads to a gradual mobilization of energy reserves in the body and to increasing deterioration of the nutritional status of patients. This will thus significantly reduce quality of life and survival of patients with a lower tolerance to cancer treatments. Despite undeniable progress in knowledge, many pathophysiological mechanisms remain few or not explored, which could explain that there is still no satisfactory therapeutic solution to halt the gradual deterioration of the nutritional status of patients. In this sense, apart from preclinical data obtained in animal models, there is currently no clinical study on the functioning of skeletal muscle energy metabolism in undernourished patients suffering of cancer.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case group | Other | the intervention, specific to the study, is to take samples on patients with advanced gastrointestinal cancer |
|
| Control group | Other | the intervention, specific to the study, is to take samples on non-undernourished patients supported for adjuvant chemotherapy as part of colorectal cancer |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Samples | Other | Blood samples, muscle biopsy and sample of hair |
|
| Measure | Description | Time Frame |
|---|---|---|
| Measurement of muscle mitochondrial bioenergetics | Measurement of muscle mitochondrial bioenergetics by high resolution oxygraphy | An average of one week |
| Measure | Description | Time Frame |
|---|---|---|
| Quantification of muscle lipid droplets | Quantification of muscle lipid droplets by electron microscopy | An average of one week |
| Analysis of the expression of target genes and proteins | Analysis of the expression of target genes and proteins involved in 1/ mitochondrial metabolism 2/ lipid metabolism 3/ the regulation of energy metabolism and 4/ muscle proteolysis by RTqPCR with SYBR Green and by Western Blot |
Not provided
Case group selection criteria:
Inclusion Criteria:
Exclusion Criteria:
Control group selection criteria:
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Thierry LECOMTE, MD-PhD | University Hospital, Tours | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Service d'Hépato-gastroentérologie et de Cancérologie Digestive, CHRU de TOURS | Tours | 37044 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35316572 | Result | Dolly A, Lecomte T, Tabchouri N, Caulet M, Michot N, Anon B, Chautard R, Desvignes Y, Ouaissi M, Fromont-Hankard G, Dumas JF, Servais S. Pectoralis major muscle atrophy is associated with mitochondrial energy wasting in cachectic patients with gastrointestinal cancer. J Cachexia Sarcopenia Muscle. 2022 Jun;13(3):1837-1849. doi: 10.1002/jcsm.12984. Epub 2022 Mar 22. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D044342 | Malnutrition |
| D005770 | Gastrointestinal Neoplasms |
| ID | Term |
|---|---|
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
Not provided
Not provided
| ID | Term |
|---|---|
| D012494 | Sampling Studies |
| ID | Term |
|---|---|
| D016020 | Epidemiologic Study Characteristics |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| An average of one week |
| Determination of body composition (fat mass / lean mass) | Determination of body composition ( fat mass / lean mass ) by an imaging method scannographic | Within 4 weeks before inclusion |
| Determining the isotopic composition of nitrogen hair | Determining the isotopic composition of nitrogen hair spectrometry . | An average of one week |
| D009369 | Neoplasms |
| D004066 | Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |