Effects of Negative Energy Balance on Muscle Mass Regulation

Effects of Negative Energy Balance on Muscle Mass Regulation

The investigators here propose to perform a prospective randomized intervention trial in post-menopausal women to investigate the endocrine network, which contributes to the changes in skeletal muscle mass during weight loss.

Inclusion Criteria:

• BMI > 27 kg/m2 (adults)
• postmenopausal state

Exclusion criteria:

• weight loss of more than 5kg in the last 2 months x
• unhealthy patients with: severe chronic diseases including cancer within the last 5 years, severe heart disease, severe impairment of hepatic or renal function, severe anaemia or disturbed coagulation
• eating disorders or any other psychiatric condition that would interact with the trial intervention
• malabsorption
• acute or chronic infections
• severe hypertension
• myopathy
• food allergies
• any other uncontrolled endocrine disorder
• changes of smoking habits, diets or medication that strongly affects energy homeostasis within the last 3 months prior to study inclusion