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This study will explore the long-term effects of exercise training on body composition, cardiorespiratory fitness, and energy metabolism in the community-dwelling elderly with sleep disturbances
This project will be conducted in three years:
In the first year,investigators will explore the correlation of sleep parameters, dietary behavior and body composition in community-dwelling elders. Two hundred elders will be recruited to receive the actigraph accelerometer recording, sleep quality questionnaire, bio-electrical impedance analysis, heart rate variability analysis, cognitive and depression evaluation.
Secondly, the study will evaluate the efficacy and possible mechanisms of a 24-week exercise training for sleep disturbances patients. Sixty patients with sleep disturbances elders will be randomized to exercise group or control group. Participants in the exercise group will receive aerobic and resistance exercise 3 times per week for 24 weeks. The controls will receive sleep hygiene education and consultation. All measurements will be performed as described before.
Finally, all the 260 elders participating in this study will receive 12-month follow-up assessments to explore the longitudinal impact of sleep disturbances on cardiorespiratory function, body composition and metabolic function, and long-term effect of exercise training on sleep disturbances patients. Investigators expect elders with poor sleep quality have lower level of health-related fitness and metabolic function; exercise training is effective to improve sleep quality, metabolic function and general health in the elders with sleep disturbances, and the effect can be sustained for a long period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise training group | Experimental | Exercise group will attend a supervised aerobic plus resistance exercise training class 3 times a week totally for 24 weeks. |
|
| Control group | No Intervention | Control group only provide standard outpatient care program. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise training group | Other | The conditioning period (24 weeks) of the exercise intervention was under the supervision of an exercise physiologist. The conditioning protocol included aerobic exercise sessions 3 times per week with 70-85% of maximal heart rate(max HR) for 30 mins and resistance sessions 3 times per week with an intensity of 80% of one-repetition maximum(1RM), 3 sets of 8 repetitions maximum. Each participant will measured the borg rating of perceived exertion scale and heart rate monitor during exercise. Exercise sessions were conducted in the afternoon (3-5 PM). |
| Measure | Description | Time Frame |
|---|---|---|
| Body fat percentage | Body fat percentage in percentage. | Up to 1 year (the first year) |
| Measure | Description | Time Frame |
|---|---|---|
| Body fat mass | Body fat mass in kilograms. | Up to 1 year (the first year) |
| Body fat free mass | Body fat free mass in kilograms. | Up to 1 year (the first year) |
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Inclusion Criteria:
1. Community dwelling sedentary men and women who were 65 years or older
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Meng-Yueh Chien, doctor | National Taiwan University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National Taiwan University | Taipei | Taiwan |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32394890 | Derived | Tseng TH, Chen HC, Wang LY, Chien MY. Effects of exercise training on sleep quality and heart rate variability in middle-aged and older adults with poor sleep quality: a randomized controlled trial. J Clin Sleep Med. 2020 Sep 15;16(9):1483-1492. doi: 10.5664/jcsm.8560. |
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| ID | Term |
|---|---|
| D012893 | Sleep Wake Disorders |
| D020447 | Parasomnias |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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|
| Body mass index | BMI in kg/m^2. | Up to 1 year (the first year) |
| Rest metabolic rate | Rest metabolic rate in percentage. | Up to 1 year (the first year) |
| Impedance | Impedance in ohm. | Up to 1 year (the first year) |
| Resistance | Resistance in ohm. | Up to 1 year (the first year) |
| Electroencephalography(EEG) | Electroencephalography was assessed during sleep. | Pretest and after 24 weeks intervention (the second year) |
| Electrooculography(EOG) | Electrooculography was assessed during sleep. | Pretest and after 24 weeks intervention (the second year) |
| Electromyography(EMG) | Electromyography was assessed during sleep. | Pretest and after 24 weeks intervention (the second year) |
| Electrocardiography(ECG) | Electrocardiography was assessed during sleep. | Pretest and after 24 weeks intervention (the second year) |
| Pittsburgh sleep quality index | Up to 1 year (the first year) |
| Dual energy X-ray absorptiometry | Pretest and after 24 weeks intervention (the second year) |
| Triglyceride | Triglyceride in mg/dL. | Pretest and after 24 weeks intervention (the second year) |
| Total cholesterol | Total cholesterol in mg/dL. | Pretest and after 24 weeks intervention (the second year) |
| Insulin | Insulin in uIU/mL. | Pretest and after 24 weeks intervention (the second year) |
| Fasting glucose | Fasting glucose in mg/dL. | Pretest and after 24 weeks intervention (the second year) |
| Glycated hemoglobin(HbA1C) | HbA1C in percentage. | Pretest and after 24 weeks intervention (the second year) |
| High-density lipoprotein | High-density lipoprotein in mg/dL. | Pretest and after 24 weeks intervention (the second year) |
| Low-density lipoprotein | Low-density lipoprotein in mg/dL. | Pretest and after 24 weeks intervention (the second year) |
| C-reactive protein | C-reactive protein in mg/dL. | Pretest and after 24 weeks intervention (the second year) |
| Heart rate variability | It is measured by the variation in the beat-to-beat interval. Methods used to detect beats is electrocardiography. | Pretest and after 24 weeks intervention (the second year) |
| Maximum oxygen consumption | Use treadmill exercise testing. | Pretest and after 24 weeks intervention (the second year) |
| Three factor eating questionnaire | Up to 1 year (the first year) |
| Taiwan Geriatric Depression Scale | Up to 1 year (the first year) |
| Groningen Activity Restriction Scale | Up to 1 year (the first year) |
| D001523 | Mental Disorders |