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Resting pupillary diameter was measured at a randomized Effect-site target concentration of propofol used as a sole anesthetic.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propofol 1 µg/ml | Experimental | Patients received a propofol infusion at an effect-site concentration of 1 µg/ml at the beginning of induction of general anesthesia for elective surgery. Pupillary diameter measurement after 10 minutes. |
|
| Propofol 2 µg/ml | Experimental | Patients received a propofol infusion at an effect-site concentration of 2 µg/ml at the beginning of induction of general anesthesia for elective surgery. Pupillary diameter measurement after 10 minutes. |
|
| Propofol 3 µg/ml | Experimental | Patients received a propofol infusion at an effect-site concentration of 3 µg/ml at the beginning of induction of general anesthesia for elective surgery. Pupillary diameter measurement after 10 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Propofol | Drug | Continuous infusion |
|
| Measure | Description | Time Frame |
|---|---|---|
| Pupillary diameter | Instantaneous measure, 10 minutes after the beginning of the study period |
| Measure | Description | Time Frame |
|---|---|---|
| Bispectral Index (BIS) | continuous measure, recorded10 minutes after the beginning of the study period | |
| Heart rate | continuous measure, recorded10 minutes after the beginning of the study period |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Isabelle Constant, MD-PHD | Hopital Armand Trousseau, Université Paris 6, Département d'anesthésie | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Departement d'anesthesie Hopital Armand Trousseau | Paris | 75012 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31490817 | Derived | Sabourdin N, Meniolle F, Chemam S, Rigouzzo A, Hamza J, Louvet N, Constant I. Effect of Different Concentrations of Propofol Used as a Sole Anesthetic on Pupillary Diameter: A Randomized Trial. Anesth Analg. 2020 Aug;131(2):510-517. doi: 10.1213/ANE.0000000000004362. |
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| ID | Term |
|---|---|
| D015742 | Propofol |
| ID | Term |
|---|---|
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
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| Pupillary diameter measurement | Device | Instantaneous measure |
|
| Observer's Assessment of Alertness/Sedation Scale (OAAS) | Clinical score | 10 minutes after the beginning of the study |
| D006838 |
| Hydrocarbons |
| D009930 | Organic Chemicals |