Monitoring Exhaled Propofol to Individualize General Anesthesia

Pilot Study to Estimate Central Propofol Effect by Measuring Exhaled Propofol Concentrations

This trial investigates the relationship between concentrations of the anesthetic drug propofol in exhaled breath, blood and drug effect in volunteers undergoing general anesthesia. The main goal of this study is to develop a pharmacokinetic - and dynamic model for propofol in exhaled breath.

Inclusion Criteria:

• 18 years of age

  • Written informed consent
  • Ability and willingness to give written informed consent
  • American Society of Anesthesiologists (ASA) risk score I

Exclusion Criteria:

• Volunteers ASA physical status II - III
• Pregnancy
• Volunteers with history of neurological disease or stroke
• Volunteers with a history of recreational drug abuse
• Volunteers with a history of alcohol abuse
• Smokers
• Anesthesia within 6 months
• Known drug allergies
• History of adverse events during general anesthesia