Effect of Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli

Effect of Short Peripheral Electrical Stimulation (PES) on Brain Response to Glucose Stimuli Evaluated by BOLD and Functional Diffusion MRI: a Crossover Pilot Study

The aims of this study are twofold: (1) to develop an innovative approach for studying brain glucose metabolism using functional diffusion weighted imaging (DWI) and BOLD fMRI in humans; (2) to evaluate the effect of short peripheral electrical stimulation (PES) treatment on brain and brain-stem targets, associated with control of food intake and energy expenditure, in response to glucose stimuli, in healthy volunteers.

Inclusion Criteria:

• Healthy volunteers
• Age 18-65 years old.
• Body mass index 18 to 25 kg/m2
• Capable of giving informed consent

Exclusion Criteria:

• Pregnancy, or nursing
• Permanent pacemakers
• Metal prosthesis
• Skin disease
• Claustrophobia
• History of neurological disorders