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Results have indicated that some dietary fibers increase fecal fat excretion and particularly viscous fibers suppress appetite sensation and reduce energy intake. Both these effects may contribute to body weight management.
Aim: The aim of the study is to investigate the potential of 3-weeks daily intake of potato pulp (FiberBind), rhamnogalacturonan I isolated potato fiber (RG-I) vs. a low-fiber control (placebo) on satiety and fecal fat excretion in healthy adults. Furthermore, a number of secondary endpoints are investigated.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| FiberBind | Experimental |
| |
| RG-I fiber | Experimental |
| |
| Placebo | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| FiberBind | Dietary Supplement | Potato pulp consisting of 68% fiber (5.5 soluble, 76.7% insoluble and 17.8% resistant starch), 9.7% water, 0.3% fat, 7.2% protein and 14% carbohydrates (starch). |
| Measure | Description | Time Frame |
|---|---|---|
| Fecal fat excretion | Based on total feces collection the last 3 days of the 21-day intervention periods | |
| Subjective appetite sensations | Assessed by visual analogue scales (VAS) | Assessed on 3-hour meal test on last day of the 21-day intervention periods |
| Measure | Description | Time Frame |
|---|---|---|
| Ad libitum energy intake | Assessed 3 hours after intake of the test meal on last day of the 21-day intervention periods | |
| Fecal energy excretion | Measured based on total feces collection the last 3 days of the 21-day intervention periods |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Copenhagen, Department of Nutrition, Exercise and Sports | Copenhagen | 1958 | Denmark |
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| ID | Term |
|---|---|
| D045602 | Steatorrhea |
| D009765 | Obesity |
| ID | Term |
|---|---|
| D008286 | Malabsorption Syndromes |
| D007410 | Intestinal Diseases |
| D005767 | Gastrointestinal Diseases |
| D004066 | Digestive System Diseases |
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| RG-I fiber | Dietary Supplement | Soluble fiber extracted from potato pulp consisting of 95% fiber and 5% water. |
|
| Placebo | Dietary Supplement | Low-fiber control |
|
| Blood lipids (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) | Measured before and after the 21-day intervention periods |
| Insulin and glucose | Measured before and after the 21-day intervention periods, and every 30 minutes during the 3-hour meal test on last day of the 21-week intervention periods |
| Gut permeability marker | Measured before and after the 21-day intervention periods |
| Gastric emptying rate (w. paracetamol) | Measured every 30 minutes during the 3-hour meal test on last day of the 21-day intervention periods |
| Gastrointestinal symptoms (questionnaire) | on day 1, 7, 14 and 22 of the 21-day intervention periods |
| Body weight | up to 21-day intervention periods |
| Blood pressure | up to 21-day intervention periods |
| Breath hydrogen | up to 21-day intervention periods |
| Gut microbiota | Measured in a fresh feces sample from day 19-21 of the intervention periods |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |