Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Nutrabolt | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to examine the acute effects of a pre-workout dietary supplement on energy metabolism, cardiovascular hemodynamics, blood metabolites and mental focus.
A number of nutritional strategies have been developed to optimize nutrient delivery prior to exercise. This includes providing carbohydrate and a number of ergogenic nutrients prior to, during and/or following exercise. As a result a number of pre-workout supplements have been developed to increase energy availability, promote vasodilation and/or positively affect exercise capacity. The purpose of this study is to investigate the potential ergogenic value of acute ingestion of a pre-workout dietary supplement prior to exercise.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| C4 Extreme | Experimental | One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine AKG, 250 mg vitamin C, 150 mg n-acetyle tyrosine, 135 mg caffeine, 7.5 mg l-dopa, 30 mg vitamin B3, 10 mg synephrine, 0.5 mg vitamin B6, 0.25 mg vitamin B9, 0.035 mg vitamin B12. |
|
| C4 Extreme (without Advantra Z) | Active Comparator | One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine AKG, 250 mg vitamin C, 150 mg n-acetyle tyrosine, 135 mg caffeine, 7.5 mg l-dopa, 30 mg vitamin B3, 0.5 mg vitamin B6, 0.25 mg vitamin B9, 0.035 mg vitamin B12. |
|
| Placebo | Placebo Comparator | One dose of flavored placebo (powder mixed with water) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| C4 Extreme | Dietary Supplement | Pre-Workout Dietary Supplement |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Optimize nutrient delivery prior to exercise by assessing; cognitive function (i.e., Stroop Color and Word Test and Word Recall Test). | Three weeks | |
| Optimize nutrient delivery prior to exercise by assessing Readiness to Perform Visual Analog Scale. | Three weeks | |
| Optimize nutrient delivery prior to exercise by assessing Resting Energy Expenditure. | Three weeks | |
| Optimize nutrient delivery prior to exercise by assessing Heart Rate. | Three weeks | |
| Optimize nutrient delivery prior to exercise by assessing Blood Pressure. | Three weeks | |
| Optimize nutrient delivery prior to exercise by assessing ECG. | Three weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Measure standard clinical chemistry panels in the blood to evaluate safety. | Three weeks | |
| Measure Heart Rate to evaluate safety. | Three weeks | |
| Measure Blood Pressure to evaluate safety. |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Richard B Kreider, PhD | Texas A&M University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Exercise & Sport Nutrition Laboratory | College Station | Texas | 77843 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28096758 | Derived | Jung YP, Earnest CP, Koozehchian M, Galvan E, Dalton R, Walker D, Rasmussen C, Murano PS, Greenwood M, Kreider RB. Effects of acute ingestion of a pre-workout dietary supplement with and without p-synephrine on resting energy expenditure, cognitive function and exercise performance. J Int Soc Sports Nutr. 2017 Jan 12;14:3. doi: 10.1186/s12970-016-0159-2. eCollection 2017. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| C4 Extreme (without Advantra Z |
| Dietary Supplement |
Pre-Workout Dietary Supplement |
|
| Placebo | Dietary Supplement | Pre-Workout Dietary Supplement |
|
| Three weeks |
| Measure ECG to evaluate safety. | Three weeks |