Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Nutrabolt | INDUSTRY |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The purpose of this study is to examine the effects of a pre-workout dietary supplement during resistance training on training adaptations.
A number of nutritional strategies have been developed to optimize nutrient delivery prior to exercise. This includes providing carbohydrate and a number of ergogenic nutrients prior to, during and/or following exercise. As a result, a number of pre-workout supplements have been developed to increase energy availability, promote vasodilation and/or positively affect exercise capacity. The purpose of this study is to investigate the effects of ingesting a pre-workout dietary supplement during resistance training on training adaptations.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| C4 Extreme | Experimental | One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine alpha-ketoglutarate, 250 mg vitamin C, 150 mg N-Acetyl-Tyrosine, 135 mg caffeine, 7.5 mg L-Dopa, 30 mg vitamin B3, 10 mg Bitter Orange (Citrus Aurantium) fruit standardized for 30% synephrine (Advantra Z), 0.5 mg vitamin B6, 0.25 mg vitamin B9, and 0.035 mg vitamin B12. |
|
| C4 Extreme (without Advantra Z) | Active Comparator | One dose of 12 grams (powder mixed with water): 1500 mg beta alanine, 1000 mg creatine nitrate, 1000 mg arginine alpha-ketoglutarate, 250 mg vitamin C, 150 mg N-Acetyl-Tyrosine, 135 mg caffeine, 7.5 mg L-Dopa, 30 mg vitamin B3, 0.5 mg vitamin B6, 0.25 mg vitamin B9, and 0.035 mg vitamin B12. |
|
| Placebo | Placebo Comparator | One dose of flavored placebo (powder mixed with water) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| C4 Extreme, C4 Extreme (without Advantra Z) | Dietary Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Examine the effects of C4 supplementation during resistance training by assessing body water | Eight weeks | |
| Examine the effects of C4 supplementation during resistance training by assessing body composition | Eight weeks | |
| Examine the effects of C4 supplementation during resistance training by assessing macronutrient intake | Eight weeks | |
| Examine the effects of C4 supplementation during resistance training by assessing 1 RM (repetition maximum) strength | Eight weeks | |
| Examine the effects of C4 supplementation during resistance training by assessing anaerobic sprint capacity | Eight weeks | |
| Examine the effects of C4 supplementation during resistance training by assessing muscle creatine levels | Eight weeks | |
| Examine the effects of C4 supplementation during resistance training by assessing muscle carnosine levels | Eight weeks | |
| Examine the effects of C4 supplementation during resistance training by assessing cognitive function (i.e., Stroop Color and Word Test, Word Recall Test and Readiness to perform VAS) | Eight weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Measure standard clinical chemistry panels in the blood to evaluate safety | Eight weeks | |
| Record side effects to evaluate safety | Eight weeks | |
| Measure heart rate to evaluate safety |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28096757 | Derived | Jung YP, Earnest CP, Koozehchian M, Cho M, Barringer N, Walker D, Rasmussen C, Greenwood M, Murano PS, Kreider RB. Effects of ingesting a pre-workout dietary supplement with and without synephrine for 8 weeks on training adaptations in resistance-trained males. J Int Soc Sports Nutr. 2017 Jan 3;14:1. doi: 10.1186/s12970-016-0158-3. eCollection 2017. |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Eight weeks |
| Measure blood pressure to evaluate safety | Eight weeks |