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| Name | Class |
|---|---|
| Queen Elizabeth Hospital NHS Foundation Trust | OTHER |
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A UK prospective, single-centre feasibility study investigating the effects of exercise therapy on functional capacity in patients on the waiting list for liver transplantation. Patients will receive a 12-week home prehabilitation program (daily step program; functional resistance exercise sessions; telephone health call or virtual clinic). The following will be assessed at weeks 0, 6 and 12 weeks: feasibility (recruitment, compliance, safety, patients perception), functional capacity (ISWT, SPBT), psychological wellbeing (HADS questionnaire) and quality of life (EQ-5D)
as above
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention arm | Experimental | 12-week home prehabilitation program |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Home prehabilitation program | Behavioral | 12-week exercise therapy using daily step program (accelerometer), functional resistance exercise sessions and telephone/virtual clinic appointments |
| Measure | Description | Time Frame |
|---|---|---|
| Number of participants with intervention-related adverse events as assessed by CTCAE v4.0 | As this is a feasibility/Pilot study the investigators need to assess if any participants have any adverse events related to the home prehabilitation programme and if so, determine the severity and frequency | 12-week |
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| Measure | Description | Time Frame |
|---|---|---|
| Functional capacity - incremental shuttle walk test | incremental shuttle walk test | 12-weeks |
| Functional capacity - short performance battery test | 12-weeks |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| James Ferguson, phD | Queen Elizabeth University Hospital Birmingham | Principal Investigator |
| Felicity Williams | Queen Elizabeth University Hospital Birmingham | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Queen Elizabeth University Hospital Birmingham | Birmingham | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29358444 | Derived | Williams FR, Vallance A, Faulkner T, Towey J, Kyte D, Durman S, Johnson J, Holt A, Perera MT, Ferguson J, Armstrong MJ. Home-based exercise therapy in patients awaiting liver transplantation: protocol for an observational feasibility trial. BMJ Open. 2018 Jan 21;8(1):e019298. doi: 10.1136/bmjopen-2017-019298. |
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| ID | Term |
|---|---|
| D008103 | Liver Cirrhosis |
| D008107 | Liver Diseases |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D004066 | Digestive System Diseases |
| D005355 | Fibrosis |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Psychological wellbeing - HADS questionnaire | HADS questionnaire | 12-weeks |
| Quality of Life - EQ-5D questionnaire | EQ-5D questionnaire | 12-weeks |
| D001519 | Behavior |