Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
The investigators aim to study the brain mechanisms underlying the effect of subliminal (not consciously perceived) intragastric administration of bitter tastants on hunger and food intake, which was previously found. The investigators will assess brain activation patterns after an acute intragastric administration of Quinine-hydrochloride versus saline on two different test days, and will simultaneously assess a putative role of altered gut peptide release in these effects. The hypothesis is that intragastric infusion of a bitter agonist will decrease the activity in homeostatic and hedonic brain regions and that this effect is mediated by gut peptide release.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Placebo Comparator | Intragastric infusion |
|
| Quinine hydrochloride | Experimental | Intragastric infusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Quinine hydrochloride | Other | Intragastric administration of a bitter tastant agonist (10 μmol/kg quinine-hydrochloride) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Functional brain images | Change in brain responses after administration compared to baseline will be assessed via functional magnetic resonance imaging. | From the start of the study until 50 minutes after the start of the study |
| Measure | Description | Time Frame |
|---|---|---|
| hunger scores | The hunger scores will be taken every 10 minutes since the scan starts via a 10 cm visual analogue scale. | every 10 minutes since the scan starts until until 50 minutes after the start of the scan |
| Ghrelin levels |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Jan Tack, Prof | University of Leuven | Principal Investigator |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D011803 | Quinine |
| ID | Term |
|---|---|
| D002930 | Cinchona Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D011812 | Quinuclidines |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Control | Other | Intragastric administration of distilled water |
|
Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure ghrelin levels by radioimmuno-assay.
| every 10 min since the scan starts until 50 minutes after the start of the scan. |
| Motilin levels | Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure motilin levels by radioimmuno-assay. | every 10 min since the scan starts until 50 minutes after the start of the scan |
| CCK levels | Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure CCK levels by radioimmuno-assay. | every 10 min since the scan starts until 50 minutes after the start of the scan |
| PYY levels | Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure PYY levels by Enzyme-Linked Immuno Sorbent Assay | every 10 min since the scan starts until 50 minutes after the start of the scan |
| GLP-1 levels | Peripheral blood samples will be taken every 10 min since the scan starts until the endpoint of the study to measure GLP-1 levels by Enzyme-Linked Immuno Sorbent Assay | every 10 min since the scan starts until 50 minutes after the start of the scan |
| D006572 |
| Heterocyclic Compounds, Bridged-Ring |
| D011804 | Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |