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The aim of this study is to investigate long-lasting or later behavioral changes in children in the context of different anesthesia techniques (Inhalation anesthesia vs. TIVA)
The process of surgery and anaesthesia can be an extremely frightening and stressful event for a child, and is frequently followed by negative postoperative behavioural changes. This Event could be associated with poor postoperative outcome and long term behavior problems like anxiety, eating or sleeping disorders. The aim of this study is to investigate long-lasting or later behavioral changes in children in the context of different anesthesia techniques (Inhalation anesthesia vs. TIVA). After anesthesia initiation, anesthesia maintenance should be done with sevoflurane or Tiva. The effect of behavioral changes in children in the context of anesthesia techniques should be evaluate by post hospitalisation behavior and Strengths and Difficulties Questionnaire at first, second and fourth week. Early postoperative problems like postoperative nausea and vomiting, pain level, pain therapy and postoperative awareness should be evaluate too.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sevoflurane group | Active Comparator | general anesthesia will be maintained with sevoflurane |
|
| TIVA group | Experimental | general anesthesia will be maintained with total intravenous anesthesia (propofol and remifentanyl) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TIVA | Procedure | TIVA is use to anesthesia maintenance after anesthesia induction (Propofol 10mg/kg/h, Remifentanil 0.2mcg/kg/min, dose adaptation as required for sufficient anesthesia) |
| Measure | Description | Time Frame |
|---|---|---|
| Post-Hospital Behaviour Questionnaire (PHBQ) score postoperatively | child's PHBQ score first week postoperatively | first week postoperative |
| Post-Hospital Behaviour Questionnaire (PHBQ) score postoperatively | child's PHBQ score second week postoperatively | second week postoperative |
| Post-Hospital Behaviour Questionnaire (PHBQ) score postoperatively | child's PHBQ score fourth week postoperatively | fourth week postoperative |
| SDQ Questionnaire score postoperatively | child's SDQ score first week postoperatively | first week postoperative |
| SDQ Questionnaire score postoperatively | child's SDQ score second week postoperatively | second week postoperative |
| SDQ Questionnaire score postoperatively | child's SDQ score fourth week postoperatively | fourth week postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| postoperative pain Level (by VAS) | Visual Analog Scale for Pain (VAS Pain) were used to evaluate postoperative pain level | in the first postoperative week (3 times a day) |
| postoperative pain Level (by CHEOPS) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Philipp Buehler, MD | University children hosptial Zurich | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Dr. Philipp Buehler | Zurich | 8032 | Switzerland |
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| ID | Term |
|---|---|
| D002652 | Child Behavior |
| D000066553 | Problem Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
| D001526 | Behavioral Symptoms |
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| ID | Term |
|---|---|
| D000077149 | Sevoflurane |
| ID | Term |
|---|---|
| D008738 | Methyl Ethers |
| D004987 | Ethers |
| D009930 | Organic Chemicals |
| D006845 | Hydrocarbons, Fluorinated |
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| Sevoflurane | Procedure | Sevoflurane is use to anesthesia maintenance after anesthesia induction (target et 2 Vol% in 50-70% N2O, dose adaptation as required) |
|
CHEOPS (Children's Hospital of Eastern Ontario Pain Scale) were used to evaluate postoperative pain level
| in the first postoperative week (3 times a day) |
| postoperative pain medication | All pain medications are recorded during the first postoperative week.Nurses and parents recorded all substance and application times by questionnaire. | in the first postoperative week |
| Intraoperative awareness | In order to record an intraoperative awareness, a semistructured interview is conducted with test questions. | in the first and second postoperative day |
| postoperative Nausea and vomiting | Nausea and Vomiting are recognized in frequency and time using a questionnaire. | in the first and second postoperative day |
| D006846 |
| Hydrocarbons, Halogenated |
| D006838 | Hydrocarbons |