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Because Propofol is the primary "anesthetic agent," and inhalational agents remain in trace quantities at the end of the procedure Sevoflurane initiated intravenous anesthesia (SIIVA) or not present at all Total intravenous anesthesia (TIVA) it is likely that different criteria may be predictive of extubation success in these patients compared to inhalational anesthesia.
This is because these anesthetic regimens have different pharmacologic mechanisms of actions, and therefore interact with central nervous system in different ways leading to potentially the need for different extubation criteria in patients receiving TIVA or SIIVA. Additionally, intravenous agents likely have less of an effect on airway reflexes and ventilation at light levels of anesthesia. This study is proposing an observational study to examine the predictive value of various extubation criteria in the setting of SIIVA and TIVA.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Total intravenous anesthesia (TIVA) | TIVA is achieved without inhalational agents and may be performed in cases where patients have an intravenous line in place prior to induction of anesthesia |
| |
| Sevoflurane initiated intravenous anesthesia (SIIVA) | SIIVA is a modification of TIVA in the setting where a patient does not tolerate the insertion of an intravenous line prior to induction of anesthesia. The patient undergoes induction of anesthesia with sevoflurane and transition to Propofol IV anesthesia for maintenance once the intravenous line is in place and discontinues the inhalational agent, sevoflurane. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Total intravenous anesthesia (TIVA) | Other | TIVA anesthetic -no inhalational gases for surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Extubation success rate | quality of extubation will be assess using a standard rubric for all extubation | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Rate of extubation that requiring intervention | desaturation, laryngospasm, airway obstruction or other issues | Day 1 |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Subjects that met specific extubation criteria | Assess the presence of specific extubation criteria met during the extubation | Day 1 |
Inclusion Criteria:
Exclusion Criteria:
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All study participants must be < 10 years of age and undergoing general anesthesia and surgery with an endotracheal tube and using a SIIVA or TIVA approach
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wes Templeton, MD | Contact | 336-716-4498 | ttemplet@wakehealth.edu | |
| Lynne Harris, BSN | Contact | 336-716-8791 | lcharris@wakehealth.edu |
| Name | Affiliation | Role |
|---|---|---|
| Thomas "Wes" Templeton, MD | Wake Forest University Health Sciences | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Atrium Health Wake Forest Baptist | Recruiting | Winston-Salem | North Carolina | 27157 | United States |
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| Sevoflurane initiated intravenous anesthesia (SIIVA) | Other | SIIVA - sevoflurane anesthetic gases for surgery |
|
| Perth Children's Hospital | Not yet recruiting | Perth | Australia |
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