Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| Weizmann Institute of Science | OTHER |
Bread is the most common grain product in the world, with consumption surpassing 3 billion individuals per year. Sourdough whole-grain bread is considered a healthy alternative to white, refined-wheat bread.
This cross-over study will test the effect of consumption of sourdough bread compared to white bread following a short dietary intervention period (one week) on multiple clinical parameters and gut microbiota.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Sourdough bread, white bread | Other | Consumption of sourdough bread for one week, 2 week washout, consumption of white bread for one week |
|
| White bread, sourdough bread | Other | Consumption of white bread for one week, 2 week washout, consumption of sourdough bread for one week |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Consumption of sourdough bread | Other | Participants will be given sourdough bread to consume instead of other wheat products. 145g will be consumed every morning in addition to ad libitum consumption throughout the day (matched between first and second intervention periods) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes to glycemic control | Measured as response to an Oral Glucose Tolerance Test (OGTT; mg/dl*h). | One week |
| Changes to glycemic control | Measured as blood glucose levels at wake-up (mg/dl). | One week |
| Measure | Description | Time Frame |
|---|---|---|
| Changes to total cholesterol levels (mg/dl) | Measured by a blood test. | One week |
| Changes to HDL cholesterol levels (mg/dl) | Measured by a blood test. |
| Measure | Description | Time Frame |
|---|---|---|
| Changes to gut microbiome composition and function | Measured by metagenomic sequencing | One week |
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Weizmann Institute of Science | Rehovot | Israel | ||||
| Department of Gastroentherology |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Consumption of white bread | Other | Participants will be given white bread to consume instead of other wheat products. 110g will be consumed every morning in addition to ad libitum consumption throughout the day (matched between first and second intervention periods) |
|
| One week |
| Changes to LDL cholesterol levels (mg/dl) | Measured by a blood test. | One week |
| Changes to triglycerides levels (mg/dl) | Measured by a blood test. | One week |
| Changes to C-Reactive Protein (CRP) levels (mg/l) | Measured by a blood test. | One week |
| Changes to weight (Kg.) | One week |
| Changes to Basal Metabolic Rate (BMR; J) | One week |
| Changes to blood pressure (mmHg) | One week |
| Changes to Alanine Transaminase (ALT) levels (IU/l) | Measured by a blood test. | One week |
| Changes to Aspartate Transaminase (AST) levels (IU/I) | Measured by a blood test. | One week |
| Changes to Gamma-Glutamyl Transpeptidase (GGT) levels (IU/l) | Measured by a blood test. | One week |
| Changes to Creatinine levels (mg/dl) | Measured by a blood test. | One week |
| Changes to Magnesium levels (mg/dl) | Measured by a blood test. | One week |
| Changes to Calcium levels (mg/dl) | Measured by a blood test. | One week |
| Changes to Iron levels (mg/dl) | Measured by a blood test. | One week |
| Changes to Urea levels (mg/dl) | Measured by a blood test. | One week |
| Changes to Lactate Dehydrogenase (LDH) levels | Measured by a blood test (IU/l) | One week |
| Changes to Thyroid Stimulating Hormone (TSH) | Measured by a blood test (mIU/ml) | One week D |
| Tel Aviv |
| 64239 |
| Israel |
| ID | Term |
|---|---|
| D001836 | Body Weight Changes |
| ID | Term |
|---|---|
| D001835 | Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
Not provided
Not provided