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Tart cherries are a rich source of antioxidants. Studies have shown that tart cherries exert anti-oxidative and anti-inflammatory properties. The purpose of this study is to learn about the effects of drinking tart cherry juice on cardiovascular and cognitive health.
Thirty-seven older adults were randomly assigned to drink 16 oz per day of either tart cherry juice or placebo drink for 12 weeks. Blood and urine samples were collected at baseline and 12 weeks to assess biomarkers. Physical activity and 3-day diet records were also collected throughout the study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tart cherry juice | Experimental | Participants consumed 16 fl. oz of tart cherry juice daily for 12 weeks. |
|
| Placebo juice | Placebo Comparator | Participants consumed 16 fl. oz of placebo daily for 12 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tart cherry juice | Other | 16 fl. oz of tart cherry juice |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive function | Change from baseline in cognitive test performance at 12 weeks | Baseline and 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular risk factors | Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in cardiovascular risk factors including blood lipid profiles, atherogenic risk ratios, blood glucose, hemoglobin A1c, insulin, and blood pressure at 12 weeks. | Baseline and 12 weeks |
| Oxidative stress markers |
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Inclusion Criteria:
• Age 65-80
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Sheau Ching Chai, PhD, RD | University of Delaware | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Delaware | Newark | Delaware | 19716 | United States |
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| Placebo |
| Other |
16 fl. oz of placebo |
|
Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in plasma 8-oxoguanine (ng/ml), plasma 8-hydroxy-2deoxy-guanosine (ng/mL), plasma hydroxynonenal (ng/ml), and plasma malondialdehyde (pmole/L) at 12 weeks. |
| Baseline and 12 weeks |
| Inflammatory markers | Fasting blood samples were collected at baseline and 12 weeks. Change from baseline in plasma tumor-necrosis factor-α (pg/mL) and plasma high-sensitivity C-reactive protein (ng/mL) at 12 weeks. | Baseline and 12 weeks |