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Diets containing fruit rich in anthocyanins have been shown (in meta-analyses) to be beneficial for health, but intervention trials have shown inconsistent results. In this preliminary study we want to investigate the influence of a tart-cherry juice intervention on vascular function and explore metabolite profiles that may offer insight into their mechanism of action
Cardiovascular disease (CVD) is the primary cause of morbidity and mortality. Tart cherries (TC) can positively impact major risk factors of CVD, activities thought to be related to their phytochemical content. However, data from human trials is less clear. TC have been shown to reduce systolic blood pressure (SBP) after acute, short-term and chronic intake, and to improve vascular dysfunction, presumably due to their antioxidant and anti-inflammatory activities. Other studies have not shown benefits of TC on SBP or vascular function and studies are difficult to interpret with different populations, dosing and durations being used as well as a lack of understanding for any underlying mechanisms. To account for the latter, the use of metabolomics has become increasingly popular in nutritional research. Therefore, the aim of this preliminary study was to characterise the effects of TC supplementation on vascular function with a 4-week intervention and explore if metabolomics can provide mechanistic evidence and this will inform for future chronic studies with TC juice.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Participants supplied with 30 ml of a low fruit (<1%) cordial mixed with maltodextrin and protein diluted in 100 ml water twice daily, once in the morning and evening. |
|
| Cherry juice | Experimental | Participants supplied with 30 ml of a tart cherry juice concentrate (CherryActive, United Kingdom; (containing 36.8 mg of anthocyanins) diluted in 100 ml of water twice daily, once in the morning and evening. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cherry juice | Dietary Supplement | A tart cherry juice intervention |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic and diastolic blood pressure | Measurement of systolic and diastolic blood pressure before and after the intervention | Change in blood pressure following 4 weeks intervention |
| Arterial pulse wave velocity | Measurement of pulse wave velocity before and after the intervention | Change in pulse wave velocity following 4 weeks intervention |
| Digital volume pulse | Measurement of digital volume pulse before and after the intervention | Change in digital volume pulse following 4 weeks intervention |
| Measure | Description | Time Frame |
|---|---|---|
| Metabolomics | Ion intensities of ca 5000 metabolites in urine samples before and after the intervention | Changes to urinary metabolite profiles following 4 weeks intervention |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Glyn Howatson | Northumbria University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Northumberland Building | Newcastle upon Tyne | NE1 7ST | United Kingdom |
Research data will be shared on request
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Randomised controlled trial
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Participants supplied with treatment or placebo in a plastic container
| Placebo |
| Dietary Supplement |
A tart cherry juice placebo |
|