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we change the study protocol
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This prospective, randomized study, control study aims to compare the analgesic effect, opioids consumption, quality of recovery, length of hospital stay and et al. between unilateral continuous quadratus lumborum block (QLB) and intravenous patient-controlled analgesia (IPCA) alone in patients undergoing hepatectomy with right J-shape subcostal incision.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Continuous QLB+postoperative IPCA | Experimental | Single-injection of QLB (quadratus lumborum block) is given preoperatively followed with continuous infusion+ postoperative IPCA (intravenous patient control analgesia) |
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| IPCA | Active Comparator | Postoperative IPCA (intravenous patient control analgesia) is given alone |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continous QLB (quadratus lumborum block) | Procedure | Inject local anesthetics in between quadratus lumborum and psoas major muscle with catheter insertion and continuous local infusion |
| Measure | Description | Time Frame |
|---|---|---|
| Cumulative morphine consumption | at 24 postoperative hours |
| Measure | Description | Time Frame |
|---|---|---|
| The pain scores determined by the numeric rating scale (NRS, 0-10) | At 0, 2,4, 8, 12, 24 ,48,72 hours and 7 day after the surgery | |
| Nausea and Vomiting score | At 0, 2,4, 8, 12, 24 and 48 hours after the surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Yuguang Huang, MD. | Peking Union Medical College Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xulei CUI | Beijing | Beijing Municipality | 100730 | China |
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| ID | Term |
|---|---|
| D000377 | Agnosia |
| ID | Term |
|---|---|
| D010468 | Perceptual Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D002404 | Catheterization |
| D000077212 | Ropivacaine |
| C052923 | isopropyl cyanoacrylate |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D008919 | Investigative Techniques |
| D000813 | Anilides |
| D000577 | Amides |
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|
| Philip CX50 Ultrasound Scanner | Device | The curved (C1-5) probe of Philip CX 50 Ultrasound Scanner is used for scan |
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| Ropivacaine | Drug |
|
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| Morphine given as IPCA | Drug | Bolus: 1-2mg, lock time: 10min, 1h limitation: 5-10mg. without background infusion. |
|
| Pruritus score | At 0, 2,4, 8, 12, 24 and 48 hours after the surgery |
| Ambulation time | within the 7 days after surgery |
| Time of recovery of bowl movement | within the 7 days after surgery |
| Quality of recovery | use the self-assessment 11 item QoR scale to assess the patient's recovery quality | 3 days and 7 days after surgery |
| Patient satisfaction with anesthesia | use the Chinese version Bauer questionnaire to assess the patient satisfaction with anesthesia | 48 hours after surgery |
| Postoperative hospital length of stay | Up to 6 weeks |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009930 |
| Organic Chemicals |
| D000814 | Aniline Compounds |
| D000588 | Amines |