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| Name | Class |
|---|---|
| San Diego State University | OTHER |
| San Ysidro Health Center | OTHER |
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Avocados are an excellent source of fiber, potassium, magnesium, and poly- and mono-unsaturated fats. They can be a nutrient dense component of healthful dietary patterns and have the potential to improve the cardiovascular disease (CVD) risk profiles of families in the United States (US). The proposed research plan will focus on the contribution of avocado intake to the reduction in CVD risk of US families, by examining the effects of avocado intake on the overall nutritional status of families. Of particular interest is establishing these effects in ethnic populations such as Hispanics/Latinos. On average, Hispanic/Latinos are at increased risk for metabolic diseases that predispose to CVD. This 6-month cluster randomized trial in Hispanic/Latino Americans aims to accurately determine the impact of avocados on the overall dietary pattern of their families. Future research will extend the results of the current trial to a larger sample of ethnically diverse families in order to evaluate whether sustained changes occur in nutritional, cardiovascular and metabolic health status.
Specific Aim 1: To determine how avocados are incorporated into the family's dietary pattern and impact selected measures of nutritional status:
Specific aim 2: To determine if increased avocado intake affects cardio-metabolic risk factors to include lipids, glucose, insulin, and HbA1c.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| High Intake Group | Experimental | Throughout the entire study, this group will be provided with 14 avocados per week and will receive 12 bi-weekly home visits over a 6-month period during which they will receive specific brochures offering "diet tips". This group will be given specific advice on avocado consumption. Each month throughout the study, we will provide opportunities for families to visit the study kitchen at the SYHC to observe the staff preparing recipes with avocado, participate in preparing recipes, and taste recipes. |
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| Low Intake Group | Active Comparator | This group will receive 3 avocados per week, as well as 12 bi-weekly home visits over a 6-month period during which they will be provided with the same educational materials (i.e., "Diet Tips") as those assigned to the "High intake" group. Participants in this group will be encouraged to improve the quality of their diets, but will not be given specific advice on avocado consumption. However, each month throughout the study, we will provide opportunities for families to visit the study kitchen at the SYHC to observe the staff preparing recipes with avocado, participate in preparing recipes, and taste recipes. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| High-intake avocados | Other | Families will receive 14 avocados on a weekly basis. |
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| Measure | Description | Time Frame |
|---|---|---|
| Change in family energy consumption at 3 and 6 months | 3 months and 6 months | |
| Change in distribution of macro and micronutrient intake at 6 months | 3 months and 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Change in cardio-metabolic risk factors by serum lipids at 6 months | 3 months and 6 months | |
| Change in cardio-metabolic risk factors by insulin at 6 months | 3 months and 6 months | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Matthew A Allison, MD, MPH | University of California, San Diego | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Bay Latino Research Center | Chula Vista | California | 91910 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37941823 | Derived | Allen TS, Doede AL, King CMB, Pacheco LS, Talavera GA, Denenberg JO, Eastman AS, Criqui MH, Allison MA. Nutritional Avocado Intervention Improves Physical Activity Measures in Hispanic/Latino Families: A Cluster RCT. AJPM Focus. 2023 Sep 20;2(4):100145. doi: 10.1016/j.focus.2023.100145. eCollection 2023 Dec. | |
| 37344091 | Derived |
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| ID | Term |
|---|---|
| D002318 | Cardiovascular Diseases |
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| Low-intake avocados |
| Other |
Families will receive 3 avocados on a weekly basis. |
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| Diet tips | Behavioral | Diet tips will come from educational materials including culturally appropriate dietary and nutritional education materials, and personalized recommendations taken from http://www.choosemyplate.gov. |
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| Avocado consumption advice | Behavioral | Recipe book with healthy recipe suggestions that include avocado. |
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| Change in cardio-metabolic risk factors by glucose at 6 months |
| 3 months and 6 months |
| Change in cardio-metabolic risk factors by computation of homeostasis model assessment at 6 months | 3 months and 6 months |
| Change in nutritional status by red blood cell fatty acid composition at 6 months | 3 months and 6 months |
| Change in nutritional status by red blood cell magnesium at 6 months | 3 months and 6 months |
| Change in nutritional status by serum total and fractionated carotenoids at 6 months | 3 months and 6 months |
| VanEvery H, Pacheco LS, Sun E, Allison MA, Gao X. The impact of avocado intake on anthropometric measures among Hispanic/Latino children and adolescents: A cluster randomized controlled trial. Clin Nutr ESPEN. 2023 Aug;56:94-103. doi: 10.1016/j.clnesp.2023.04.020. Epub 2023 May 3. |