Valuation of Variable Dose of Docosahexanoic Acid for the Improvement of the Parameters of Male Fertility

Valuation of Variable Dose of Docosahexanoic Acid for the Improvement of the Parameters of Male Fertility

Sperm parameters will be examined before DHA (DHA=Docosahexanoic Acid) consumption, after one months and after 2 months taken Docosahexanoic Acid or placebo.

Prospective, randomized, double blind, placebo-controlled intervention study within individuals. Assisted reproduction unit and academic research laboratory. One hundred an eighty human semen samples from 60 infertile patients of IVI Sevilla clinic were finally included. Assessment of oxidative stress, apoptosis, lipid peroxidation, mitochondrial membrane potential, DNA fragmentation and standard sperm parameters before and after supplementation with different DHA doses (0.5, 1 and 2 g) or placebo for 1 and 3 months.

Inclusion criteria:

• 1 year of infertility
• > 10 mill/ml of sperms
• Motility < 60% progressive
• Morphology < 2% (WHO 2010)

Exclusion criteria:

No meeting the inclusion criteria.