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Sperm parameters will be examined before DHA (DHA=Docosahexanoic Acid) consumption, after one months and after 2 months taken Docosahexanoic Acid or placebo.
Prospective, randomized, double blind, placebo-controlled intervention study within individuals. Assisted reproduction unit and academic research laboratory. One hundred an eighty human semen samples from 60 infertile patients of IVI Sevilla clinic were finally included. Assessment of oxidative stress, apoptosis, lipid peroxidation, mitochondrial membrane potential, DNA fragmentation and standard sperm parameters before and after supplementation with different DHA doses (0.5, 1 and 2 g) or placebo for 1 and 3 months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo | Placebo Comparator | Placebo |
|
| 500 mg DHA/day | Active Comparator | 500 mg DHA/day |
|
| 1g DHA/day | Active Comparator | 1g DHA/day |
|
| 2g DHA/day | Active Comparator | 2g DHA/day |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DHA | Dietary Supplement |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Sperm cell concentration | Measured in millions of sperm cells per ml of semen sample | Three months |
| Sperm cell motility | Measured in percentage of each type of motile sperm according to OMS 2010 criteria (A-D). | Three months |
| Sperm cell morphology | Measured in percentage of sperm cell with normal morphology according to OMS 2010 criteria. | Three |
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Inclusion criteria:
Exclusion criteria:
No meeting the inclusion criteria.
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| ID | Term |
|---|---|
| D007248 | Infertility, Male |
| ID | Term |
|---|---|
| D005832 | Genital Diseases, Male |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007246 | Infertility |
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| ID | Term |
|---|---|
| D004281 | Docosahexaenoic Acids |
| ID | Term |
|---|---|
| D015525 | Fatty Acids, Omega-3 |
| D004042 | Dietary Fats, Unsaturated |
| D004041 | Dietary Fats |
| D005223 | Fats |
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| Placebo |
| Other |
|
| D052801 |
| Male Urogenital Diseases |
| D008055 |
| Lipids |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D005395 | Fish Oils |
| D009821 | Oils |