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Numerous studies have recommended the use of n-3 PUFA supplementation during human pregnancy and lactation for the prevention of preterm birth, beneficial effects on fetal development, visual and cognitive development and other functional outcomes of the infants.
The aim of the present study is to assess the correlation between ratio of n-3:n-6 fatty acid and inflammation markers in SGA infants compared with appropriate for gestational age (AGA) infants. The investigators hypothesize that in SGA infants n-3 and n-6 fatty acid concentrations in cord blood will differ from those observed in AGA and might correlate with the level of circulating mediators.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Blood test in Mothers of SGA Infants | In mothers of Small for Gestational Age (SGA) Infants, maternal and cord blood test will be performed |
| |
| Blood test in Mothers of AGA infants | In mothers of Appropriate for Gestational Age (AGA) Infants, maternal and cord blood test will be performed |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Blood test | Procedure | Blood will be drawn from mother's vein and from the cord to test for n-6:n-3 ratio and inflammatory markers: CRP, IL-6, TPO and TNF-alpha markers |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cord blood analysis | Determination of the cord blood values of inflammatory markers (CRP, IL-6, TPO, TNF-alpha) and of the n-6:n-3 ratio | at time of delivery |
| Measure | Description | Time Frame |
|---|---|---|
| Maternal blood analysis | Determination of the maternal blood values of inflammatory markers (CRP, IL-6, TPO, TNF-alpha) and of n-6:n-3 ratio | at time of delivery |
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Inclusion Criteria:
Exclusion Criteria:
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Mothers of term or or near term infants after delivery
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Dror Mandel, MD | Contact | +97236925690 | drorm@tlvmc.gov.il |
| Name | Affiliation | Role |
|---|---|---|
| Dror Mandel, MD | Department of Neonatology, Lis Maternity Hospital, Tel Aviv Medical Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sourasky medical center (Ichilov) | Recruiting | Tel Aviv | Israel |
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Whole blood
| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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