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To see if there is a relationship between the level of LIF in IUGR fetuses and compared to the level of LIF in AGA fetuses
During embryonic development, there are several cytokines such as: LIF (Leukemia inhibitory factor), ciliary neurotrophic factor (CNTF), epidermal growth factor family (EGF), neuregulin 1 (NRG1) and transforming growth factor β (TGFβ) that were found are associated with neurogenesis and differentiation of brain cells .
LIF is a cytokine that is essential for the development of the central nervous system, and has recently been shown in rats that maternal LIF stimulates placental ACTH that in turn promotes secretion of fetal LIF from nRBC , which in turn promotes brain development of the fetus Other studies on IUGR (Intra Uterine Growth Restriction) have shown that IUGR fetuses have more CP (Cerebral palsy) than those who were AGA (Average for Gestational Age) The hypothesis is that LIF is related to the proper development of the nervous system in the fetus and by testing cord blood of embryos IUGR and the placenta we will find changes in LIF and ACTH compared with AGA fetuses level.
Studies have also shown a relationship between CP and IUGR, but the mechanism for this relationship is unclear.
The purpose of our research is to see if there is a relationship between the level of LIF in IUGR fetuses and compared to the level of LIF in AGA fetuses, in one of two ways:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | Women with IUGR embryos so that their fetal weight estimate puts them in a percentile bellow 10th percentile |
| |
| IUGR | Women with AGA embryos so that their fetal weight estimate puts them in a percentile between 20th and 80th percentiles |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood sample and tissue sample | Other | After birth and fetal umbilical cord disconnection, a blood sample will be taken from the umbilical cord (cord blood) of IUGR and of AGA fetuses (5cc) for cytokine ELISA testing. Also a small sample of the placenta will be examined in order to assess the level of ACTH protein in IUGR and AGA embryos |
| Measure | Description | Time Frame |
|---|---|---|
| LIF Protein Level in IUGR Neonates vs. AGA neonates | 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Pregnant women with fetuses who are AGA and those with fetuses that are IUGR
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D006650 | Histocompatibility Testing |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Cord blood and a small peace of the placenta
|
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D007159 | Immunologic Tests |
| D007158 | Immunologic Techniques |