Study of the Level of a Protein Which Could Predict the Development of a Fungal Infection in Patients With Acute Leukemia

Study of the Level of Mannose Binding Lectin (MBL) as a Predictor of the Onset of a Invasive Fungal Infection (IFI) During Chemo-induced Aplasia in Patients With Acute Leukemia (AL)

The aim of this study is to investigate levels of a protein, mannose binding lectin, in patients with acute leukemia who develop or not an invasive fungal infection.

Inclusion Criteria :

• persons who have provided written consent
• Patients with national health insurance cover
• Patients with malignant hemopathy who have been treated with chemotherapy able to induce profound neutropenia (PN < 500 / mm3) lasting more than 10 days.
• Patients with malignant hemopathy who have received an autologous bone marrow graft
• Patients with severe idiopathic medullar aplasia (PN < 500 / mm3) who need to be hospitalized for at least 10 consecutive days (with or without treatment with immunosuppressants)

Exclusion Criteria:

• Patients who have received an bone marrow PSC allograft (as such patients have a risk of aspergillosis, which appears in most cases after medullar recovery; they will not be included in the study).
• Patients who have received an autologous PSC graf (as the duration of neutropenia is in most cases less than 10 days).
• Patients whose neutropenia, retrospectively assessed, lasted less than 10 days.